Alternative splicing as a source of phenotypic diversity
A major goal of evolutionary genetics is to understand the genetic processes that give rise to
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
The role of alternative splicing in adaptation and evolution
Regulation of gene expression plays a central role in adaptive divergence and evolution.
Although the role of gene regulation in microevolutionary processes is gaining wide …
Although the role of gene regulation in microevolutionary processes is gaining wide …
Applications of next generation sequencing in molecular ecology of non-model organisms
As most biologists are probably aware, technological advances in molecular biology during
the last few years have opened up possibilities to rapidly generate large-scale sequencing …
the last few years have opened up possibilities to rapidly generate large-scale sequencing …
Principles of transcriptome analysis and gene expression quantification: an RNA‐seq tutorial
JBW Wolf - Molecular ecology resources, 2013 - Wiley Online Library
Genome‐wide analyses and high‐throughput screening was long reserved for biomedical
applications and genetic model organisms. With the rapid development of massively parallel …
applications and genetic model organisms. With the rapid development of massively parallel …
Alternative splicing and the evolution of phenotypic novelty
Alternative splicing, a mechanism of post-transcriptional RNA processing whereby a single
gene can encode multiple distinct transcripts, has been proposed to underlie morphological …
gene can encode multiple distinct transcripts, has been proposed to underlie morphological …
New gene evolution: little did we know
Genes are perpetually added to and deleted from genomes during evolution. Thus, it is
important to understand how new genes are formed and how they evolve to be critical …
important to understand how new genes are formed and how they evolve to be critical …
Challenges and strategies in transcriptome assembly and differential gene expression quantification. A comprehensive in silico assessment of RNA‐seq experiments
Transcriptome S hotgun S equencing (RNA‐seq) has been readily embraced by geneticists
and molecular ecologists alike. As with all high‐throughput technologies, it is critical to …
and molecular ecologists alike. As with all high‐throughput technologies, it is critical to …
Speciation genetics: current status and evolving approaches
JBW Wolf, J Lindell… - … Transactions of the …, 2010 - royalsocietypublishing.org
The view of species as entities subjected to natural selection and amenable to change put
forth by Charles Darwin and Alfred Wallace laid the conceptual foundation for understanding …
forth by Charles Darwin and Alfred Wallace laid the conceptual foundation for understanding …
A quantitative framework for characterizing the evolutionary history of mammalian gene expression
The evolutionary history of a gene helps predict its function and relationship to phenotypic
traits. Although sequence conservation is commonly used to decipher gene function and …
traits. Although sequence conservation is commonly used to decipher gene function and …
SpliceGrapher: detecting patterns of alternative splicing from RNA-Seq data in the context of gene models and EST data
We propose a method for predicting splice graphs that enhances curated gene models
using evidence from RNA-Seq and EST alignments. Results obtained using RNA-Seq …
using evidence from RNA-Seq and EST alignments. Results obtained using RNA-Seq …