BACKGROUND Autophagy is an intracellular catabolic process of degrading and recycling
proteins and organelles to modulate various physiological and pathological events …

Reproduction is characterized by a series of massive renovations at molecular, cellular, and
tissue levels. Recent studies have strongly tended to reveal the involvement of basic …

Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in
Leydig cells. However, the role and mechanism of ADM in the pyroptosis of Leydig cells are …

Macroautophagy/autophagy is indispensable for testosterone synthesis in Leydig cells
(LCs), and here we report a negative association between m6A modification and autophagy …

The fundamental framework of steroidogenesis is similar across steroidogenic cells,
especially in initial mitochondrial steps. For instance, the START domain containing protein …

Testosterone is indispensable for sexual development and maintaining male characteristics,
and deficiency of this hormone results in primary or late-onset hypogonadism (LOH) …

Spermatogenesis is a complex process in the testis and is a cornerstone of male infertility.
The abundance of unsaturated fatty acid and high cell division rate make male germs cells …

Leydig cells are essential for steroidogenesis and spermatogenesis. An imbalance in the
production of reactive oxygen species (ROS) and the cellular antioxidant level brings about …

Autophagy is a conserved degradation process crucial to maintaining the primary function of
cellular and organismal metabolism. Impaired autophagy could develop numerous …

The evolutionary theory of aging supports a trade-off relationship between reproduction and
aging. Aging of the male reproductive system primarily affects the testes, leading to a …