Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

Cancer chemotherapy is frequently hampered by drug resistance, so the resistance to
anticancer agents represents one of the major obstacles for the effective cancer treatment …

Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …

Indole, an aza-heterocyclic scaffold, has been found one of the most privileged scaffolds in
heterocyclic chemistry and drug discovery. Efforts have been made to provide the complete …

Introduction Spirocyclic scaffolds are an exceptional tool in drug design, allowing fine-tuning
of a molecule's conformational and physicochemical properties. As it expands and …

Ketones and aldehydes are employed as enol O-nucleophiles in an iridium-catalyzed
asymmetric allylic substitution reaction. The reaction proceeds well in the presence of a well …

Outside of Mycobacterium tuberculosis and Mycobacterium leprae, nontuberculous
mycobacteria (NTM) are environmental mycobacteria (> 190 species) and are classified as …

Rhodium-catalyzed intramolecular cyclization of nitrogen-tethered allenols was investigated
for the synthesis of functionalized morpholines. By using this strategy, various N-protected 2 …

Disruption of redox homeostasis in mycobacteria causes irreversible stress induction and
cell death. Here, we report the dioxonaphthoimidazolium scaffold as a novel redox cycling …

In this report, a library consisting of three sets of indole-piperazine derivatives was designed
through the molecular hybridization approach. In total, fifty new hybrid compounds (T1-T50) …