Discoveries have emerged highlighting the complex nature of the interorgan cross-talk
between the kidney and the lung. Vascular rigidity, neurohormonal activation, tissue …

Rationale: Comorbidities contribute to disease severity and mortality in patients with chronic
obstructive pulmonary disease (COPD). Comorbidities have been studied individually and …

Chronic kidney disease (CKD) is a progressive disease that affects> 10% of the total
population worldwide or> 800 million people. CKD poses a particularly heavy burden in low …

Rationale: The diagnosis of chronic obstructive pulmonary disease (COPD) is based on a
low FEV1/FVC ratio, but the severity of COPD is classified using FEV1% predicted (ppFEV1) …

Motivation Integration of data from different modalities is a necessary step for multi-scale
data analysis in many fields, including biomedical research and systems biology. Directed …

BACKGROUND: The association between HIV and emphysema remains incompletely
understood. We sought to determine whether HIV is an independent risk factor for …

Rationale: Patients with chronic obstructive pulmonary disease (COPD) frequently have
albuminuria (indicative of renal endothelial cell injury) associated with hypoxemia …

Background Cardiovascular diseases, osteoporosis, and depression are identified
comorbidities of chronic obstructive pulmonary disease (COPD), but there have been few …

Rationale: Lower FEV1 is associated with increased prevalence of atherosclerosis;
however, causal mechanisms remain elusive. Objectives: To determine if systemic …

Cellular senescence–defined as a stable cell-cycle arrest combined with stereotyped
phenotypic changes–might play a causal role in various lung diseases, including chronic …