Glycosaminoglycans: what remains to be deciphered?

S Perez, O Makshakova, J Angulo, E Bedini, A Bisio… - Jacs Au, 2023 - ACS Publications
Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural
diversity and fulfilling various functions mediated by thousands of interactions in the …

Spike-heparan sulfate interactions in SARS-CoV-2 infection

FL Kearns, DR Sandoval, L Casalino… - Current opinion in …, 2022 - Elsevier
Recent biochemical, biophysical, and genetic studies have shown that heparan sulfate, a
major component of the cellular glycocalyx, participates in infection of SARS-CoV-2 by …

Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2

L Liu, P Chopra, X Li, KM Bouwman… - ACS Central …, 2021 - ACS Publications
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is causing an
unprecedented global pandemic demanding the urgent development of therapeutic …

Virtual screening and molecular dynamics simulations provide insight into repurposing drugs against SARS-CoV-2 variants Spike protein/ACE2 interface

D Pirolli, B Righino, C Camponeschi, F Ria… - Scientific Reports, 2023 - nature.com
After over two years of living with Covid-19 and hundreds of million cases worldwide there is
still an unmet need to find proper treatments for the novel coronavirus, due also to the rapid …

[HTML][HTML] Endothelial cells and SARS-CoV-2: An intimate relationship

LC Barbosa, TL Goncalves, LP de Araujo… - Vascular …, 2021 - Elsevier
Abstract Angiotensin-converting enzyme 2 (ACE2) is an important player of the renin-
angiotensin-aldosterone system (RAAS) in regulating the conversion of angiotensin II into …

Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation

Q Zhang, W Tang, E Stancanelli, E Jung, Z Syed… - Nature …, 2023 - nature.com
SARS-CoV-2 infection causes spike-dependent fusion of infected cells with ACE2 positive
neighboring cells, generating multi-nuclear syncytia that are often associated with severe …

Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors

A Wu, K Shi, J Wang, R Zhang, Y Wang - European Journal of Medicinal …, 2024 - Elsevier
The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …

Deuterated drugs and biomarkers in the COVID-19 pandemic

RD Jansen-van Vuuren, L Jedlovčnik, J Košmrlj… - ACS …, 2022 - ACS Publications
Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Initially identified in Wuhan …

Polymers inspired by heparin and heparan sulfate for viral targeting

M Hoffmann, NL Snyder, L Hartmann - Macromolecules, 2022 - ACS Publications
Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Antiviral strategies using natural source-derived sulfated polysaccharides in the light of the COVID-19 pandemic and major human pathogenic viruses

B Ray, I Ali, S Jana, S Mukherjee, S Pal, S Ray… - Viruses, 2021 - mdpi.com
Only a mere fraction of the huge variety of human pathogenic viruses can be targeted by the
currently available spectrum of antiviral drugs. The severe acute respiratory syndrome …