Regulation of CRISPR-Cas9 functions in vivo is conducive to developing precise therapeutic
genome editing. Here, we report a CRISPR-Cas9 prodrug nanosystem (termed …

Brown adipose tissue (BAT) activity contributes to cardiovascular health by its energy-
dissipating capacity but how BAT modulates vascular function and atherosclerosis through …

Myeloid-derived growth factor (MYDGF) is a paracrine protein produced by bone marrow-
derived monocytes and macrophages. Current research shows that it has protective effects …

Whether bone marrow modulates systemic metabolism remains unknown. Our recent study
suggested that myeloid-derived growth factor (MYDGF) improves insulin resistance. Here …

Podocytes are unique, highly specialized, terminally differentiated cells, which are restricted
in a post-mitotic state with limited ability to repair or regenerate. Re-entering the mitotic …

Biomimetic cell membrane camouflaged technology has drawn extensive attention as a
feasible and efficient way to realize the biological functions of nanoparticles from the parent …

Lipid metabolism is a critical component in preserving homeostasis and health, and lipids
are significant chemicals involved in energy metabolism in living things. With the growing …

Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood
flow initiates liver growth in mice by vasodilation and mechanically-triggered release of …

BACKGROUND: Inflammation contributes to the pathogenesis of atherosclerosis. But little is
known about the potential benefits of inflammatory cells to atherosclerosis. The aim of this …

Innate lymphoid cells (ILCs) are a diverse population of cells that include NK cells and
contribute to tissue homeostasis and repair, inflammation, and provide protection from …