Reverse screening methods to search for the protein targets of chemopreventive compounds

H Huang, G Zhang, Y Zhou, C Lin, S Chen, Y Lin… - Frontiers in …, 2018 - frontiersin.org
This article is a systematic review of reverse screening methods used to search for the
protein targets of chemopreventive compounds or drugs. Typical chemopreventive …

Using reverse docking for target identification and its applications for drug discovery

A Lee, K Lee, D Kim - Expert opinion on drug discovery, 2016 - Taylor & Francis
Introduction: In contrast to traditional molecular docking, inverse or reverse docking is used
for identifying receptors for a given ligand among a large number of receptors. Reverse …

AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway

L Deng, W Bao, B Zhang, S Zhang, Z Chen, X Zhu… - Cell Death & …, 2023 - nature.com
Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy and is characterized by
highly aggressive and malignant biological behavior. Currently, effective treatment …

Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo

F Dehghan, F Hajiaghaalipour, A Yusof, S Muniandy… - Scientific reports, 2016 - nature.com
Saffron is consumed as food and medicine to treat several illnesses. This study elucidates
the saffron effectiveness on diabetic parameters in-vitro and combined with resistance …

Saffron (Crocus sativus L.): Phytochemistry, therapeutic significance and omics-based biology

D Pandita - Medicinal and aromatic plants, 2021 - Elsevier
Crocus sativus L.(Saffron) is an economically vital medicinal and aromatic plant. Saffron is
known as the “Golden Condiment” being the world's highest priced spice (€ 30,000/kg) …

Identification of proapoptopic, anti-inflammatory, anti-proliferative, anti-invasive and anti-angiogenic targets of essential oils in cardamom by dual reverse virtual …

B Bhattacharjee, J Chatterjee - Asian Pacific Journal of Cancer …, 2013 - koreascience.kr
Background: Cardamom (Elettaria cardamom), also known as" Queen of Spices", has been
traditionally used as a culinary ingredient due to its pleasant aroma and taste. In addition to …

The effects of saffron supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis

M Zamani, M Zarei, M Nikbaf-Shandiz, F Gholami… - Frontiers in …, 2022 - frontiersin.org
Introduction Cardiovascular disease (CVD) is one of the leading causes of death and
disability in the world and is estimated to involve more people in the next years. It is said that …

Anti‐tumor effects of crocetin and related molecular targets

M Moradzadeh, HR Sadeghnia… - Journal of Cellular …, 2018 - Wiley Online Library
Natural products have gained a wide popularity as chemopreventive and anti‐cancer agents
owing to their multi‐mechanistic mode of action, availability and synergism with several …

Identification of anti-cancer targets of eco-friendly waste Punica granatum peel by dual reverse virtual screening and binding analysis

T Usha, AK Goyal, S Lubna, HP Prashanth… - Asian Pacific journal …, 2015 - koreascience.kr
Background: Punica granatum (family: Lythraceae) is mainly found in Iran, which is
considered to be its primary centre of origin. Studies on pomegranate peel have revealed …

Does saffron supplementation have favorable effects on liver function indicators? A systematic review and meta-analysis of randomized controlled trials

SM Mousavi, P Mokhtari, O Asbaghi, S Rigi… - Critical Reviews in …, 2022 - Taylor & Francis
Several pharmaceutical and non-pharmaceutical approaches have been suggested to
improve liver health. There is a large discrepancy in the effects of saffron supplementation …