[HTML][HTML] Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options

T Karampatakis, K Tsergouli, P Behzadi - Antibiotics, 2023 - mdpi.com
Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

[HTML][HTML] Klebsiella species: Taxonomy, hypervirulence and multidrug resistance

N Dong, X Yang, EWC Chan, R Zhang, S Chen - EBioMedicine, 2022 - thelancet.com
Members of the genus Klebsiella have rapidly evolved within the past decade, generating
organisms that simultaneously exhibit both multidrug resistance and hypervirulence (MDR …

[HTML][HTML] Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation

S Federici, S Kredo-Russo, R Valdés-Mas… - Cell, 2022 - cell.com
Human gut commensals are increasingly suggested to impact non-communicable diseases,
such as inflammatory bowel diseases (IBD), yet their targeted suppression remains a …

Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a …

M Wang, M Earley, L Chen, BM Hanson… - The Lancet Infectious …, 2022 - thelancet.com
Summary Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global
threat. We therefore analysed the bacterial characteristics of CRKP infections and the …

[HTML][HTML] Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen

CL Gorrie, M Mirčeta, RR Wick, LM Judd… - Nature …, 2022 - nature.com
Klebsiella pneumoniae is a major cause of opportunistic healthcare-associated infections,
which are increasingly complicated by the presence of extended-spectrum beta-lactamases …

[HTML][HTML] IntegronFinder 2.0: identification and analysis of integrons across bacteria, with a focus on antibiotic resistance in Klebsiella

B Néron, E Littner, M Haudiquet, A Perrin, J Cury… - Microorganisms, 2022 - mdpi.com
Integrons are flexible gene-exchanging platforms that contain multiple cassettes encoding
accessory genes whose order is shuffled by a specific integrase. Integrons embedded within …

[HTML][HTML] A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings

HA Thorpe, R Booton, T Kallonen, MJ Gibbon… - Nature …, 2022 - nature.com
The Klebsiella group, found in humans, livestock, plants, soil, water and wild animals, is
genetically and ecologically diverse. Many species are opportunistic pathogens and can …

Klebsiella pneumoniae carbapenemase variants resistant to ceftazidime-avibactam: an evolutionary overview

CA Hobson, G Pierrat, O Tenaillon… - Antimicrobial agents …, 2022 - Am Soc Microbiol
First variants of the Klebsiella pneumoniae carbapenemase (KPC), KPC-2 and KPC-3, have
encountered a worldwide success, particularly in K. pneumoniae isolates. These beta …

Kaptive 2.0: updated capsule and lipopolysaccharide locus typing for the Klebsiella pneumoniae species complex

MMC Lam, RR Wick, LM Judd, KE Holt… - Microbial …, 2022 - microbiologyresearch.org
The outer polysaccharide capsule and lipopolysaccharide (LPS) antigens are key targets for
novel control strategies targeting Klebsiella pneumoniae and related taxa from the K …

[HTML][HTML] Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

AC Dowell, MS Butler, E Jinks, G Tut, T Lancaster… - Nature …, 2022 - nature.com
SARS-CoV-2 infection is generally mild or asymptomatic in children but a biological basis for
this outcome is unclear. Here we compare antibody and cellular immunity in children (aged …