Phospholipase C (PLC) converts phosphatidylinositol 4, 5-bisphosphate (PIP2) to inositol 1,
4, 5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular …

Phosphoinositide-specific phospholipase C (PLC) subtypes β, γ, and δ comprise a related
group of multidomain phosphodiesterases that cleave the polar head groups from inositol …

Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth
muscle (ASM) functions including contraction, growth, and" synthetic" functions that …

The mechanism of receptor-induced activation of the ubiquitously expressed family of
mammalian canonical transient receptor potential (TRPC) channels has been the focus of …

The 5‐hydroxytryptamine 5‐HT1A receptor was one of the first G protein coupled receptors
whose cDNA and gene were isolated by molecular cloning methods. Transfection of the …

Recent years have witnessed an increasing interest in neuron–glia communication. This
interest stems from the realization that glia participate in cognitive functions and information …

Abstract THE hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PtdInsP2) is a
widespread receptor-coupled signalling system at the plasma membrane of most eukaryotic …

Proteinase-activated receptor-2 (PAR-2) is a G-protein-coupled receptor that is expressed
by intestinal epithelial cells, which are episodically exposed to pancreatic trypsin in the …

Activation of cell-surface receptors by appropriate ligands causes the generation of second
messengers which are released in the cell interior. Such transmembrane signalling …

The myristoylated alanine-rich protein kinase C substrate (MARCKS) is a major protein
kinase C (PKC) substrate in many different cell types. MARCKS is bound to the plasma …