Epithelial-to-mesenchymal transition: lessons from development, insights into cancer and the potential of EMT-subtype based therapeutic intervention
Epithelial-to-mesenchymal transition (EMT) is a fundamental developmental process
wherein polarized epithelial cells lose their junctional architecture and apical-basal polarity …
wherein polarized epithelial cells lose their junctional architecture and apical-basal polarity …
Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis
M Lehmann, L Buhl, HN Alsafadi, S Klee… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive
injury and reprogramming of the lung epithelium are thought to be critical drivers of disease …
injury and reprogramming of the lung epithelium are thought to be critical drivers of disease …
Nucleotides and nucleoside signaling in the regulation of the epithelium to mesenchymal transition (EMT)
AS Martínez-Ramírez, M Díaz-Muñoz… - Purinergic …, 2017 - Springer
The epithelium-mesenchymal transition (EMT) is an important process of cell plasticity,
consisting in the loss of epithelial identity and the gain of mesenchymal characteristics …
consisting in the loss of epithelial identity and the gain of mesenchymal characteristics …
GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification
Abstract Epithelial-mesenchymal transition (EMT), a biological process by which polarized
epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to …
epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to …
[HTML][HTML] Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with …
JC Thompson, WT Hwang, C Davis, C Deshpande… - Lung cancer, 2020 - Elsevier
Objectives Treatment of non-small cell lung cancer (NSCLC) with immune checkpoint
blockade (ICB) has resulted in striking clinical responses, but only in a subset of patients …
blockade (ICB) has resulted in striking clinical responses, but only in a subset of patients …
The role of GRHL2 and epigenetic remodeling in epithelial–mesenchymal plasticity in ovarian cancer cells
Cancer cells exhibit phenotypic plasticity during epithelial–mesenchymal transition (EMT)
and mesenchymal–epithelial transition (MET) involving intermediate states. To study …
and mesenchymal–epithelial transition (MET) involving intermediate states. To study …
Co-delivery of bufalin and nintedanib via albumin sub-microspheres for synergistic cancer therapy
Y Xu, Y Liu, Q Liu, S Lu, X Chen, W Xu, F Shi - Journal of Controlled …, 2021 - Elsevier
Albumin nanoparticles represent an approved anti-tumor drug delivery system. However,
there is only one albumin nanoparticle product (paclitaxel-albumin nanoparticle) on the …
there is only one albumin nanoparticle product (paclitaxel-albumin nanoparticle) on the …
[HTML][HTML] Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial–mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic …
M Yamaguchi, S Hirai, Y Tanaka, T Sumi… - Laboratory …, 2017 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease of
unknown cause. IPF has a distinct histopathological pattern of usual interstitial pneumonia in …
unknown cause. IPF has a distinct histopathological pattern of usual interstitial pneumonia in …
Recognition Imaging of Trace E-cadherins on the Bladder Cancer Cells Surface during Epithelial–Mesenchymal Transition by Force–Distance Curve-Based AFM
M Zhang, J Qin, X Guo, Z Li, C Rankl, B Zhang… - Nano Letters, 2023 - ACS Publications
Tumor-associated epithelial-mesenchymal transition (EMT) contains a set of transitional
cellular states usually judged by the EMT marker expression. E-cadherin is a down …
cellular states usually judged by the EMT marker expression. E-cadherin is a down …
[HTML][HTML] Celecoxib targets breast cancer stem cells by inhibiting the synthesis of prostaglandin E2 and down-regulating the Wnt pathway activity
C Huang, Y Chen, H Liu, J Yang, X Song, J Zhao… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Pharmacological targeting of breast cancer stem cells (CSCs) is highly promising for the
treatment of breast cancer, as the small population of CSCs is responsible for tumor …
treatment of breast cancer, as the small population of CSCs is responsible for tumor …