In order to address the world-wide health challenge caused by the COVID-19 pandemic, the
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …

EPH receptors (EPHs), the largest family of tyrosine kinases, phosphorylate downstream
substrates upon binding of ephrin cell surface–associated ligands. In a large cohort of …

Activin receptor type 1 (ACVR1; ALK2) and activin receptor like type 1 (ACVRL1; ALK1) are
transforming growth factor beta family receptors that integrate extracellular signals of bone …

Reactive fragment (RF) screening has emerged as an efficient method for ligand discovery
across the proteome, irrespective of a target's perceived tractability. To date, however, the …

DNA-encoded library technology grants access to nearly infinite opportunities to explore the
chemical structure space for drug discovery. Successful navigation depends on the design …

In vitro screening of large compound libraries with automated high-throughput screening is
expensive and time-consuming and requires dedicated infrastructures. Conversely, the …

Sažetak Molecules that act on the biological target at micromolar level at least are called
hits. The usual method for identifying hits is high-throughput screening (HTS) of chemical …

Peptidomimetics, a class of compounds that bridge the gap between peptides and small
molecules, have emerged as a transformative class of compounds in drug discovery and …

A recent report discovered a chloro-hydantoin lead for COVID-19 antiviral therapy, however,
effects of stereochemical changes of the spiro-cycle and halogens were not examined …