Cardiac energy metabolism in heart failure

GD Lopaschuk, QG Karwi, R Tian, AR Wende… - Circulation …, 2021 - Am Heart Assoc
Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Pharmacological and nutritional agents promoting browning of white adipose tissue

ML Bonet, P Oliver, A Palou - … et Biophysica Acta (BBA)-Molecular and Cell …, 2013 - Elsevier
The role of brown adipose tissue in the regulation of energy balance and maintenance of
body weight is well known in rodents. Recently, interest in this tissue has re-emerged due to …

Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms

Y Zhang, K Guo, RE LeBlanc, D Loh, GJ Schwartz… - Diabetes, 2007 - Am Diabetes Assoc
Leucine, as an essential amino acid and activator of mTOR (mammalian target of
rapamycin), promotes protein synthesis and suppresses protein catabolism. However, the …

Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism

P She, C Van Horn, T Reid… - American Journal …, 2007 - journals.physiology.org
Elevations in branched-chain amino acids (BCAAs) in human obesity were first reported in
the 1960s. Such reports are of interest because of the emerging role of BCAAs as potential …

Leucine nutrition in animals and humans: mTOR signaling and beyond

F Li, Y Yin, B Tan, X Kong, G Wu - Amino Acids, 2011 - Springer
Macronutrients, such as protein or amino acid, not only supply calories but some
components may also play as signaling molecules to affect feeding behavior, energy …

Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle

P She, TM Reid, SK Bronson, TC Vary, A Hajnal… - Cell metabolism, 2007 - cell.com
Leucine is recognized as a nutrient signal; however, the long-term in vivo consequences of
leucine signaling and the role of branched-chain amino acid (BCAA) metabolism in this …

Amino acid supplementation and impact on immune function in the context of exercise

VF Cruzat, M Krause, P Newsholme - … of the international Society of Sports …, 2014 - Springer
Moderate and chronic bouts of exercise may lead to positive metabolic, molecular, and
morphological adaptations, improving health. Although exercise training stimulates the …

[HTML][HTML] Leucine metabolism in T cell activation: mTOR signaling and beyond

EA Ananieva, JD Powell, SM Hutson - Advances in nutrition, 2016 - Elsevier
In connection with the increasing interest in metabolic regulation of the immune response,
this review discusses current advances in understanding the role of leucine and leucine …

Complex energy metabolic changes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction

KA De Jong, GD Lopaschuk - Canadian Journal of Cardiology, 2017 - Elsevier
Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex, and are dependent …

[图书][B] Paleoanthropology and archaeology of big-game hunting

JD Speth - 2012 - Springer
Regardless of what particular academic track you may have followed as a college
undergraduate, whether it was paleoanthropology, archaeology, biology, geosciences, or …