The great migration of bone marrow-derived stem cells toward the ischemic brain: therapeutic implications for stroke and other neurological disorders

CV Borlongan, LE Glover, N Tajiri, Y Kaneko… - Progress in …, 2011 - Elsevier
Accumulating laboratory studies have implicated the mobilization of bone marrow (BM)-
derived stem cells in brain plasticity and stroke therapy. This mobilization of bone cells to the …

The anti-inflammatory properties of mesenchymal stem cells in epilepsy: Possible treatments and future perspectives

V Salari, F Mengoni, F Del Gallo, G Bertini… - International Journal of …, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent adult cells with self-renewing capacities.
MSCs display specific properties, such as the ability to repair damaged tissues, resulting in …

Therapeutic potential of mesenchymal stem cells in the treatment of epilepsy and their interaction with antiseizure medications

MR Tesiye, M Gol, MR Fadardi, SNM Kani, AM Costa… - Cells, 2022 - mdpi.com
Epilepsy is a life-threatening neurological disease that affects approximately 70 million
people worldwide. Although the vast majority of patients may be successfully managed with …

Neuroimmune interaction in seizures and epilepsy: focusing on monocyte infiltration

DB Bosco, DS Tian, LJ Wu - The FEBS journal, 2020 - Wiley Online Library
Epilepsy is a major neurological condition that affects millions of people globally. While a
number of interventions have been developed to mitigate this condition, a significant number …

The dose-response effect of acute intravenous transplantation of human umbilical cord blood cells on brain damage and spatial memory deficits in neonatal hypoxia …

S De Paula, S Greggio, DR Marinowic, DC Machado… - Neuroscience, 2012 - Elsevier
Despite the beneficial effects of cell-based therapies on brain repair shown in most studies,
there has not been a consensus regarding the optimal dose of human umbilical cord blood …

Multiple Autologous Bone Marrow-Derived CD271+ Mesenchymal Stem Cell Transplantation Overcomes Drug-Resistant Epilepsy in Children

O Milczarek, D Jarocha… - Stem cells …, 2018 - academic.oup.com
There is a need among patients suffering from drug-resistant epilepsy (DRE) for more
efficient and less toxic treatments. The objective of the present study was to assess the …

Concise review: prospects of bone marrow mononuclear cells and mesenchymal stem cells for treating status epilepticus and chronic epilepsy

S Agadi, AK Shetty - Stem Cells, 2015 - academic.oup.com
Mononuclear cells (MNCs) and mesenchymal stem cells (MSCs) derived from the bone
marrow and other sources have received significant attention as donor cells for treating …

Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in …

ZSM Costa-Ferro, BSF Souza, MMT Leal… - Neurobiology of …, 2012 - Elsevier
Approximately 30% of patients with mesial temporal lobe epilepsy do not respond to
treatment with antiepileptic drugs. We have previously shown that transplantation of …

Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus

S Fukumura, M Sasaki, Y Kataoka-Sasaki, S Oka… - Epilepsy Research, 2018 - Elsevier
Objective Status epilepticus (SE) causes neuronal cell death, aberrant mossy fiber sprouting
(MFS), and cognitive deteriorations. The present study tested the hypothesis that …

Depression comorbidity in epileptic rats is related to brain glucose hypometabolism and hypersynchronicity in the metabolic network architecture

G Zanirati, PN Azevedo, GT Venturin, S Greggio… - …, 2018 - Wiley Online Library
Objective Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy
syndromes in the world. Depression is an important comorbidity of epilepsy, which has been …