Evidence from biochemistry, genetics, and electron microscopy strongly supports the idea
that a ring of Synaptotagmin is central to the clamping and release of synaptic vesicles (SVs) …

Synaptic vesicles are organelles with a precisely defined protein and lipid composition,, yet
the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown. Here …

GABAB receptor (GBR) activation inhibits neurotransmitter release in axon terminals in the
brain, except in medial habenula (MHb) terminals, which show robust potentiation. However …

Simple Summary The diagnostic value of exosomes has been well recognized by
researchers. The use of exosomal biomarkers as an adjunct diagnosis method not only …

Synaptotagmin-1 (Syt1) is a calcium sensor that regulates synaptic vesicle fusion in
synchronous neurotransmitter release. Syt1 interacts with negatively charged lipids and the …

Neurotransmitters are released from synaptic vesicles with remarkable precision in
response to presynaptic calcium influx but exhibit significant heterogeneity in exocytosis …

The biggest challenge in current isolation methods for lipid bilayer‐encapsulated vesicles,
such as exosomes, secretory, and synthetic vesicles, lies in the absence of a unified …

Intercellular communication in the nervous system occurs through the release of
neurotransmitters into the synaptic cleft between neurons. In the presynaptic neuron, the …

Various cell types release neurotransmitters, hormones and many other compounds that are
stored in secretory vesicles by exocytosis via the formation of a fusion pore traversing the …

Abstract Purpose [18F] SynVesT-1 is a novel radiopharmaceutical for assessing synaptic
density in vivo. This study aims to investigate the potential of [18F] SynVesT-1 positron …