The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Notch signalling links the fate of one cell to that of an immediate neighbour and
consequently controls differentiation, proliferation and apoptotic events in multiple metazoan …

Structural variants (SVs), including small insertion and deletion variants (indels), are
challenging to detect through standard alignment-based variant calling methods. Sequence …

Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome …

Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm with
variations in gene expression profiles and genetic alterations, which lead to substantial …

Allergic disease represents a significant global health burden, and disease incidence
continues to rise in urban areas of the world. As such, a better understanding of the basic …

Notch receptors influence cellular behavior by participating in a seemingly simple signaling
pathway, but outcomes produced by Notch signaling are remarkably varied depending on …

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago,
Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a …

The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in
adults, is still largely unknown. The full spectrum of genetic lesions that are present in the …

The four receptors of the Notch family are widely expressed transmembrane proteins that
function as key conduits through which mammalian cells communicate to regulate cell fate …