This paper is focused on unique insights provided by the preterm lamb physiological model
of bronchopulmonary dysplasia (BPD). Connections are also made to insights provided by …

Adults and children may have different reactions to inhalation exposures due to differences
in target tissue doses following similar exposures, and/or different stages in lung growth and …

Analysis of lineage relationships in the naphthalene-injured tracheal epithelium
demonstrated that two multipotential keratin 14–expressing cells (K14ECs) function as …

It has been postulated that mucus stasis is central to the pathogenesis of obstructive lung
diseases. In Scnn1b-transgenic (Scnn1b-Tg+) mice, airway-targeted overexpression of the …

Tracheal brush cells (BCs) are specialized epithelial chemosensors that use the canonical
taste transduction cascade to detect irritants. To test whether BCs are replaced at the same …

Overexpression of the epithelial Na+ channel β subunit (Scnn1b gene, βENaC protein) in
transgenic (Tg) mouse airways dehydrates mucosal surfaces, producing mucus obstruction …

Recent studies link early rhinovirus (RV) infections to later asthma development. We
hypothesized that neonatal RV infection leads to an IL-13–driven asthma-like phenotype in …

Occupational exposure to butter flavoring vapors (BFV) is associated with significant
pulmonary injury. The goal of the current study was to characterize inhalation dosimetric …

Ozone, a pervasive environmental pollutant, adversely affects functional lung growth in
children. Animal studies demonstrate that altered lung development is associated with …

Asthma is a worldwide health problem that affects 300 million people, as estimated by the
World Health Organization. A key question in light of this statistic is:“what is the most …