Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …

Bilirubin, an abundant bile pigment in mammalian serum, was once considered a toxic
waste product and has more recently been recognized as a potent antioxidant of …

There is strong evidence that serum free bilirubin concentration has significant effects on
morbidity and mortality in the most significant health conditions of our times, including …

Immunometabolism is emerging as a critical determinant of cancer pathophysiology. In this
study, we explored the contributions of macrophage-expressed lactate dehydrogenase-A …

Bilirubin, the principal bile pigment, is the end product of heme catabolism. For many years,
bilirubin was thought to have no physiological function other than that of a waste product of …

The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic
syndrome. This review reflects the dramatic increase in research on the role of increased …

Hepatic ischemia-reperfusion injury (IRI) remains a major concern in liver transplantation
and resection, despite continuing efforts to prevent it. Accumulating evidence suggests that …

There are still controversies concerning the role of immunological mechanisms engaged
both in recurrent abortions (RA) and pre-eclampsia (PE). According to some opinions …

Obesity-induced endoplasmic reticulum (ER) stress causes chronic inflammation in adipose
tissue and steatosis in the liver, and eventually leads to insulin resistance and type 2 …

Islets isolated from multiple pancreas donors are often necessary to achieve euglycemia in
type 1 diabetic patients treated by islet allotransplantation. This increases the burden on the …