The miRNA: a small but powerful RNA for COVID-19
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is a severe and rapidly evolving epidemic. Now …
syndrome coronavirus 2 (SARS-CoV-2) is a severe and rapidly evolving epidemic. Now …
Inhibition of Histone Deacetylase 6 (HDAC6) as a therapeutic strategy for Alzheimer's disease: A review (2010–2020)
Y Li, S Sang, W Ren, Y Pei, Y Bian, Y Chen… - European journal of …, 2021 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which is
characterized by the primary risk factor, age. Several attempts have been made to treat AD …
characterized by the primary risk factor, age. Several attempts have been made to treat AD …
DrugMAP: molecular atlas and pharma-information of all drugs
The efficacy and safety of drugs are widely known to be determined by their interactions with
multiple molecules of pharmacological importance, and it is therefore essential to …
multiple molecules of pharmacological importance, and it is therefore essential to …
POSREG: proteomic signature discovered by simultaneously optimizing its reproducibility and generalizability
Mass spectrometry-based proteomic technique has become indispensable in current
exploration of complex and dynamic biological processes. Instrument development has …
exploration of complex and dynamic biological processes. Instrument development has …
DRESIS: the first comprehensive landscape of drug resistance information
X Sun, Y Zhang, H Li, Y Zhou, S Shi… - Nucleic acids …, 2023 - academic.oup.com
Widespread drug resistance has become the key issue in global healthcare. Extensive
efforts have been made to reveal not only diverse diseases experiencing drug resistance …
efforts have been made to reveal not only diverse diseases experiencing drug resistance …
Molecular mechanism for the allosteric inhibition of the human serotonin transporter by antidepressant escitalopram
W Xue, T Fu, S Deng, F Yang, J Yang… - ACS chemical …, 2022 - ACS Publications
Human serotine transporter (hSERT) is one of the most influential drug targets, and its
allosteric modulators (eg, escitalopram) have emerged to be the next-generation medication …
allosteric modulators (eg, escitalopram) have emerged to be the next-generation medication …
VARIDT 2.0: structural variability of drug transporter
The structural variability data of drug transporter (DT) are key for research on precision
medicine and rational drug use. However, these valuable data are not sufficiently covered …
medicine and rational drug use. However, these valuable data are not sufficiently covered …
PFmulDL: a novel strategy enabling multi-class and multi-label protein function annotation by integrating diverse deep learning methods
Bioinformatic annotation of protein function is essential but extremely sophisticated, which
asks for extensive efforts to develop effective prediction method. However, the existing …
asks for extensive efforts to develop effective prediction method. However, the existing …
ConSIG: consistent discovery of molecular signature from OMIC data
The discovery of proper molecular signature from OMIC data is indispensable for
determining biological state, physiological condition, disease etiology, and therapeutic …
determining biological state, physiological condition, disease etiology, and therapeutic …
Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning
J Hong, Y Luo, Y Zhang, J Ying, W Xue… - Briefings in …, 2020 - academic.oup.com
Functional annotation of protein sequence with high accuracy has become one of the most
important issues in modern biomedical studies, and computational approaches of …
important issues in modern biomedical studies, and computational approaches of …