Pancreatic ductal adenocarcinoma (PDAC) is correlated with poor outcomes because of
limited therapeutic options. Laminin-5 gamma-2 (LAMC2) plays a critical role in key …

Tyrosine kinases inhibitors (TKIs) revolutionized chronic myeloid leukemia (CML) treatment
for many years, prolonging patients' life expectancy to be comparable to age-matched …

Abstract Sperm-associated antigen 9 (SPAG9) is a new member of cancer testis antigen and
belongs to c-Jun NH2-terminal kinase (JNK) interacting protein (JIP) family. SPAG9 is highly …

Background Breast cancer is the second leading cause of cancer related deaths in women
worldwide. Reports about the early diagnosis of breast cancer are suggestive of an …

Ovarian cancer is one of the neoplasms affecting the reproductive tract associated with high
mortality rate because of limited therapeutic options and an elevated incidence of …

Background Protein tyrosine phosphatase receptor gamma (PTPRG) is a ubiquitously
expressed member of the protein tyrosine phosphatase family known to act as a tumor …

Prostate cancer (PCa) is a worldwide malignant tumor which seriously threats the
reproductive health of middle-aged and senior male. Sperm-associated antigen 9 (SPAG9) …

Abstract Treatment with imatinib mesylate and other tyrosine kinase inhibitors (TKI)
revolutionized the therapy of chronic myeloid leukemia (CML). However, it alone does not …

Colorectal cancer ranks third among the estimated cancer cases and cancer related
mortalities in United States in 2014. Early detection and efficient therapy remains a …

Renal fibrosis is controlled by profibrotic and antifibrotic forces. Exploring anti-fibrosis factors
and mechanisms is an attractive strategy to prevent organ failure. Here we identified the JNK …