beta‐hydroxysteroid dehydrogenases (11β‐HSDs) catalyse the conversion of active 11‐
hydroxy glucocorticoids (cortisol, corticosterone) and their inert 11‐keto forms (cortisone, 11 …

Depression is a common psychiatric disease caused by various factors, manifesting with
continuous low spirits, with its precise mechanism being unclear. Early life stress (ELS) is …

Abstract 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity is implicated as a
moderator of the progression of multiple diseases and disorders in medicine and is actively …

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis represents one of the most
consistent pathophysiological findings in depressive disorders. Cortisol signaling is affected …

Major depressive disorder (MDD) is a severe mental illness characterized by a lack of
objective biomarkers. Mounting evidence suggests there are extensive transcriptional …

The pharmacokinetic parameters of paroxetine vary between individuals, leading to
differences in efficacy. The focus of our research was to predict responses to paroxetine …

In this paper, we presented the design by computational tools of novel alkyl (2-alcoxy-2-
hydroxypropanoyl)-L-tryptophanate derivatives, which can be potential inhibitors of 11β …

自杀是全球重大的公共卫生问题, 在全球范围内都是主要的死亡原因之一,
给人类造成巨大的社会经济损失和心理伤害. 抑郁症是自杀死亡的首要原因 …

Suicide is a major global public health concern and is one of the leading causes of death
worldwide, causing enormous socioeconomic losses and psychological damage to human …