About 30per4cent of drug candidate molecules are rejected due to pharmacokinetic-related
failures. When poor pharmaceutical properties are discovered in development, the costs of …

Explains how to perform and analyze the results of the latest physicochemical methods With
this book as their guide, readers have access to all the current information needed to …

The measurement of physicochemical properties at an early phase of drug discovery and
development is crucial to reduce attrition rates due to poor biopharmaceutical properties …

Abstract Evaluation of a multiplexed capillary electrophoresis (CE) method for pK a
measurements of organic compounds, including low solubility compounds, is presented …

The pKa values of 25 structurally diverse drug compounds including mono-, di-and tri-protic
molecules were determined by a recently developed multi-wavelength spectrophotometric …

Equations have been presented for calculating lipophilicity profiles from pH data in
conjunction with pKa and log P values. Shake‐flask and pH‐metric methods for measuring …

The mixed dissociation constants of four non-steroidal anti-inflammatory drugs (NSAIDs)
ibuprofen, diclofenac sodium, flurbiprofen and ketoprofen at various ionic strengths I of …

A procedure is described for measuring p K a values in a short time, eg, 4 min/assay.
Samples, as 10 mM solutions, are prepared in DMSO in 96-well plates. A flowing pH …

Potentiometric and spectrophotometric titrations were used for the determination of
ionization behaviour, lipophilicity and solubility profile of repaglinide. Acid–base equilibria …

The acid–base dissociation constant, p K a, is a key parameter to define the ionization state
of a compound and directly affects its biopharmaceutical profile. In this study, we developed …