Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this
insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding …

Cell-identity switches, in which terminally differentiated cells are converted into different cell
types when stressed, represent a widespread regenerative strategy in animals, yet they are …

Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the
considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and …

Lack of rapid revascularization and inflammatory attacks at the site of transplantation
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …

Although regenerative medicine products are at the forefront of scientific research,
technological innovation, and clinical translation, their reproducibility and large-scale …

Diabetes is one of the most socially challenging health concerns. Even though islet
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …

Diabetes mellitus (DM) ranks among the severest global health concerns of the 21st century.
It encompasses a group of chronic disorders characterized by a dysregulated glucose …