[HTML][HTML] Towards organoid culture without Matrigel
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …
function in miniature—are of growing interest in developmental biology and medicine …
Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
Charting cellular identity during human in vitro β-cell differentiation
A Veres, AL Faust, HL Bushnell, EN Engquist… - Nature, 2019 - nature.com
In vitro differentiation of human stem cells can produce pancreatic β-cells; the loss of this
insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding …
insulin-secreting cell type underlies type 1 diabetes. Here, as a step towards understanding …
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells
Cell-identity switches, in which terminally differentiated cells are converted into different cell
types when stressed, represent a widespread regenerative strategy in animals, yet they are …
types when stressed, represent a widespread regenerative strategy in animals, yet they are …
[HTML][HTML] Towards a better understanding of diabetes mellitus using organoid models
BS Beydag-Tasöz, S Yennek… - Nature Reviews …, 2023 - nature.com
Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …
investigations and work in model organisms and cell lines. Organoid models for a wide …
[HTML][HTML] Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
F Lebreton, V Lavallard, K Bellofatto, R Bonnet… - Nature …, 2019 - nature.com
Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the
considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and …
considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and …
[HTML][HTML] Bio-engineering of pre-vascularized islet organoids for the treatment of type 1 diabetes
CH Wassmer, F Lebreton, K Bellofatto… - Transplant …, 2022 - frontierspartnerships.org
Lack of rapid revascularization and inflammatory attacks at the site of transplantation
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …
[HTML][HTML] Automation, monitoring, and standardization of cell product manufacturing
MN Doulgkeroglou, A Di Nubila, B Niessing… - … in Bioengineering and …, 2020 - frontiersin.org
Although regenerative medicine products are at the forefront of scientific research,
technological innovation, and clinical translation, their reproducibility and large-scale …
technological innovation, and clinical translation, their reproducibility and large-scale …
[HTML][HTML] Making human pancreatic islet organoids: Progresses on the cell origins, biomaterials and three-dimensional technologies
L Jiang, Y Shen, Y Liu, L Zhang, W Jiang - Theranostics, 2022 - ncbi.nlm.nih.gov
Diabetes is one of the most socially challenging health concerns. Even though islet
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …
[HTML][HTML] Stem-cell based organ-on-a-chip models for diabetes research
Diabetes mellitus (DM) ranks among the severest global health concerns of the 21st century.
It encompasses a group of chronic disorders characterized by a dysregulated glucose …
It encompasses a group of chronic disorders characterized by a dysregulated glucose …