Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

Aberrant DNA methylation plays a pivotal role in tumor development and progression. DNA
hypomethylating agents (HMA) constitute a class of drugs which are able to reverse DNA …

Pediatric and young adult (YA) patients with acute myeloid leukemia (AML) who relapse
after allogeneic hematopoietic cell transplantation (HCT) have an extremely poor prognosis …

CD8+ exhausted T cells (Tex) are heterogeneous. PD-1 inhibitors reinvigorate progenitor
Tex, which subsequently differentiate into irresponsive terminal Tex. The ability to maintain a …

Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic
development, growth, and metastatic dissemination in a process called cancer …

Autoimmune disorders (ADs) are encountered in 10 to 20% of patients with myelodysplastic
syndromes (MDS). Available data suggest that ADs concern more often younger patients …

Over the last two decades, several epi‐drugs, immune checkpoint inhibitors (ICIs) and
adoptive cell therapies have received clinical approval for use in certain types of cancer …

Myelodysplastic syndrome (MDS) is a heterogeneous hematological malignancy,
characterized by cytopenia and accompanied by a risk of transformation into acute myeloid …

The tumor immune microenvironment represents a sophisticated ecosystem where various
immune cell subtypes communicate with cancer cells and stromal cells. The dynamic …

Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and
elimination of stressed, transformed, or virus-infected cells. They critically shape the …