Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

Liver cancer and disease are among the most socially challenging global health concerns.
Although organ transplantation, surgical resection and anticancer drugs are the main …

Cancer relapse after chemotherapy remains a main cause of cancer-related death. Although
the relapse is thought to result from the propagation of resident cancer stem cells, a lack of …

Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs),
but following injury, dedifferentiation results in the emergence of LGR5− ve regenerative …

Background & Aims Cancer-associated fibroblasts (CAFs) play a key role in the cancer
process, but the research progress is hampered by the paucity of preclinical models that are …

Tumor‐initiating cells are major drivers of chemoresistance and attractive targets for cancer
therapy, however, their identity in human pancreatic ductal adenocarcinoma (PDAC) and the …

The past decade has seen many advancements in the development of three-dimensional
(3D) in vitro models in pharmaceutical sciences and industry. Specifically, organoids present …

Objective Hepatocellular carcinoma (HCC) has high intratumoral heterogeneity, which
contributes to therapeutic resistance and tumour recurrence. We previously identified …

Hepatocellular carcinoma (HCC) remains the most predominant type of liver cancer with an
extremely poor prognosis due to its late diagnosis and high recurrence rate. One of the …

Organoid culture systems have emerged as a frontier technology in liver and biliary
research. These three‐dimensional (3D) cell cultures derived from pluripotent and adult …