[HTML][HTML] Advancement in solubilization approaches: a step towards bioavailability enhancement of poorly soluble drugs
L Kumari, Y Choudhari, P Patel, GD Gupta, D Singh… - Life, 2023 - mdpi.com
A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …
is currently a major hurdle in bringing new drug molecules to the market. According to some …
[HTML][HTML] Simulation-based approaches for drug delivery systems: navigating advancements, opportunities, and challenges
I Salahshoori, M Golriz, MAL Nobre, S Mahdavi… - Journal of Molecular …, 2023 - Elsevier
Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals'
targeted and effective administration. However, the intricate interplay between drug …
targeted and effective administration. However, the intricate interplay between drug …
[HTML][HTML] Measurement and modeling of dapagliflozin propanediol monohydrate (an anti-diabetes medicine) solubility in supercritical CO2: Evaluation of new model
G Sodeifian, H Nateghi, F Razmimanesh - Journal of CO2 Utilization, 2024 - Elsevier
The solubility of dapagliflozin propanediol monohydrate (DPM) in supercritical carbon
dioxide (SC-CO 2) was determined for the first time. The operating temperature and …
dioxide (SC-CO 2) was determined for the first time. The operating temperature and …
Therapeutic potential of natural products in inflammation: Underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives
Chronic inflammation is a common underlying factor in many major diseases, including
heart disease, diabetes, cancer, and autoimmune disorders, and is responsible for up to …
heart disease, diabetes, cancer, and autoimmune disorders, and is responsible for up to …
[HTML][HTML] Liposome-derived nanosystems for the treatment of behavioral and neurodegenerative diseases: the promise of niosomes, transfersomes, and ethosomes for …
PC Pires, AC Paiva-Santos, F Veiga - Pharmaceuticals, 2023 - mdpi.com
Psychiatric and neurodegenerative disorders are amongst the most prevalent and
debilitating diseases, but current treatments either have low success rates, greatly due to the …
debilitating diseases, but current treatments either have low success rates, greatly due to the …
[HTML][HTML] Application of design of experiments in the development of self-microemulsifying drug delivery systems
CM Hsieh, TL Yang, AD Putri, CT Chen - Pharmaceuticals, 2023 - mdpi.com
Oral delivery has become the route of choice among all other types of drug administrations.
However, typical chronic disease drugs are often poorly water-soluble, have low dissolution …
However, typical chronic disease drugs are often poorly water-soluble, have low dissolution …
Promising strategies for improving oral bioavailability of poor water-soluble drugs
B Rocha, LA de Morais, MC Viana… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Oral administration of poorly water-soluble drugs (PWSDs) is generally related
to low bioavailability, leading to high drug doses, multiple side effects, and low patient …
to low bioavailability, leading to high drug doses, multiple side effects, and low patient …
Mechanosynthesis of Stable Salt Hydrates of Allopurinol with Enhanced Dissolution, Diffusion, and Pharmacokinetics
Allopurinol (ALO) is a medication that treats gout and kidney stones by lowering uric acid
synthesis in the blood. The biopharmaceutics classification system (BCS) IV drug exhibits …
synthesis in the blood. The biopharmaceutics classification system (BCS) IV drug exhibits …
Development strategies of polymorphs and solvates for enhancing powder properties: A case study of thiothiamine
R Han, H Qu, Y Li, Y Liu, T Tao, W Tang… - Crystal Growth & …, 2023 - ACS Publications
Crystals with an acicular shape are a “nightmare” to many chemical engineers due to their
poor powder properties, posing numerous challenges in purification, filtration, washing, and …
poor powder properties, posing numerous challenges in purification, filtration, washing, and …
Nuciferine-loaded chitosan hydrogel-integrated 3D-printed polylactic acid scaffolds for bone tissue engineering: A combinatorial approach
R Bharathi, G Harini, A Sankaranarayanan… - International Journal of …, 2023 - Elsevier
Critical-sized bone defects resulting from severe trauma and open fractures cannot
spontaneously heal and require surgical intervention. Limitations of traditional bone grafting …
spontaneously heal and require surgical intervention. Limitations of traditional bone grafting …