S100A8 and S100A9 in Cancer

Y Chen, Y Ouyang, Z Li, X Wang, J Ma - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract S100A8 and S100A9 are Ca 2+ binding proteins that belong to the S100 family.
Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in …

Mechanism and therapeutic potential of tumor-immune symbiosis in glioblastoma

L Pang, F Khan, AB Heimberger, P Chen - Trends in cancer, 2022 - cell.com
Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor in human adults.
Myeloid-lineage cells, including macrophages, microglia, myeloid-derived suppressor cells …

Brain co‐delivery of temozolomide and cisplatin for combinatorial glioblastoma chemotherapy

Y Zou, Y Wang, S Xu, Y Liu, J Yin… - Advanced …, 2022 - Wiley Online Library
Glioblastoma (GBM) is an intractable malignancy with high recurrence and mortality.
Combinatorial therapy based on temozolomide (TMZ) and cisplatin (CDDP) shows …

Mutant IDH inhibits IFNγ–TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

MJ Wu, L Shi, J Dubrot, J Merritt, V Vijay, TY Wei… - Cancer discovery, 2022 - AACR
Abstract Isocitrate dehydrogenase 1 mutations (mIDH1) are common in
cholangiocarcinoma.(R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits …

Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy

H Yu, J Liu, X Bu, Z Ma, Y Yao, J Li, T Zhang… - Cell Chemical …, 2024 - cell.com
The tumor microenvironment (TME) is a heterogeneous ecosystem containing cancer cells,
immune cells, stromal cells, cytokines, and chemokines which together govern tumor …

Nitric oxide release activated near-Infrared photothermal agent for synergistic tumor treatment

Y Xu, S Wang, Z Chen, R Hu, Y Zhao, K Wang, J Qu… - Biomaterials, 2021 - Elsevier
Activatable phototherapeutic agents (PTA) in one system with synergistic gas therapy (GT)
and photothermal therapy (PTT) hold great promise for highly efficient tumor treatments. In …

Tumor-associated macrophages/CXC motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling

B Yang, G Li, S Wang, Y Zheng, J Zhang, B Pan… - Cell death & …, 2024 - nature.com
Autophagy-mediated chemoresistance is the core mechanism for therapeutic failure and
poor prognosis in breast cancer. Breast cancer chemotherapy resistance is believed to be …

Uncovering spatiotemporal heterogeneity of high-grade gliomas: From disease biology to therapeutic implications

A Comba, SM Faisal, ML Varela, T Hollon… - Frontiers in …, 2021 - frontiersin.org
Glioblastomas (GBM) are the most common and aggressive tumors of the central nervous
system. Rapid tumor growth and diffuse infiltration into healthy brain tissue, along with high …

Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade

S Goswami, D Raychaudhuri, P Singh, SM Natarajan… - Nature Cancer, 2023 - nature.com
Glioblastoma (GBM) tumors are enriched in immune-suppressive myeloid cells and are
refractory to immune checkpoint therapy (ICT). Targeting epigenetic pathways to reprogram …

Intracavitary Spraying of Nanoregulator‐Encased Hydrogel Modulates Cholesterol Metabolism of Glioma‐Supportive Macrophage for Postoperative Glioblastoma …

Y Dong, J Zhang, Y Wang, Y Zhang… - Advanced …, 2024 - Wiley Online Library
Glioblastoma multiforme (GBM) is notoriously resistant to immunotherapy due to its intricate
immunosuppressive tumor microenvironment (TME). Dysregulated cholesterol metabolism …