S100A8 and S100A9 in Cancer
Y Chen, Y Ouyang, Z Li, X Wang, J Ma - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract S100A8 and S100A9 are Ca 2+ binding proteins that belong to the S100 family.
Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in …
Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in …
Mechanism and therapeutic potential of tumor-immune symbiosis in glioblastoma
Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor in human adults.
Myeloid-lineage cells, including macrophages, microglia, myeloid-derived suppressor cells …
Myeloid-lineage cells, including macrophages, microglia, myeloid-derived suppressor cells …
Brain co‐delivery of temozolomide and cisplatin for combinatorial glioblastoma chemotherapy
Glioblastoma (GBM) is an intractable malignancy with high recurrence and mortality.
Combinatorial therapy based on temozolomide (TMZ) and cisplatin (CDDP) shows …
Combinatorial therapy based on temozolomide (TMZ) and cisplatin (CDDP) shows …
Mutant IDH inhibits IFNγ–TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
Abstract Isocitrate dehydrogenase 1 mutations (mIDH1) are common in
cholangiocarcinoma.(R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits …
cholangiocarcinoma.(R)-2-hydroxyglutarate generated by the mIDH1 enzyme inhibits …
Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy
H Yu, J Liu, X Bu, Z Ma, Y Yao, J Li, T Zhang… - Cell Chemical …, 2024 - cell.com
The tumor microenvironment (TME) is a heterogeneous ecosystem containing cancer cells,
immune cells, stromal cells, cytokines, and chemokines which together govern tumor …
immune cells, stromal cells, cytokines, and chemokines which together govern tumor …
Nitric oxide release activated near-Infrared photothermal agent for synergistic tumor treatment
Activatable phototherapeutic agents (PTA) in one system with synergistic gas therapy (GT)
and photothermal therapy (PTT) hold great promise for highly efficient tumor treatments. In …
and photothermal therapy (PTT) hold great promise for highly efficient tumor treatments. In …
Tumor-associated macrophages/CXC motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling
B Yang, G Li, S Wang, Y Zheng, J Zhang, B Pan… - Cell death & …, 2024 - nature.com
Autophagy-mediated chemoresistance is the core mechanism for therapeutic failure and
poor prognosis in breast cancer. Breast cancer chemotherapy resistance is believed to be …
poor prognosis in breast cancer. Breast cancer chemotherapy resistance is believed to be …
Uncovering spatiotemporal heterogeneity of high-grade gliomas: From disease biology to therapeutic implications
Glioblastomas (GBM) are the most common and aggressive tumors of the central nervous
system. Rapid tumor growth and diffuse infiltration into healthy brain tissue, along with high …
system. Rapid tumor growth and diffuse infiltration into healthy brain tissue, along with high …
Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade
Glioblastoma (GBM) tumors are enriched in immune-suppressive myeloid cells and are
refractory to immune checkpoint therapy (ICT). Targeting epigenetic pathways to reprogram …
refractory to immune checkpoint therapy (ICT). Targeting epigenetic pathways to reprogram …
Intracavitary Spraying of Nanoregulator‐Encased Hydrogel Modulates Cholesterol Metabolism of Glioma‐Supportive Macrophage for Postoperative Glioblastoma …
Y Dong, J Zhang, Y Wang, Y Zhang… - Advanced …, 2024 - Wiley Online Library
Glioblastoma multiforme (GBM) is notoriously resistant to immunotherapy due to its intricate
immunosuppressive tumor microenvironment (TME). Dysregulated cholesterol metabolism …
immunosuppressive tumor microenvironment (TME). Dysregulated cholesterol metabolism …