Abstract In 1968, Heskins and Guillet published the first systematic study of the phase
diagram of poly (N‐isopropylacrylamide)(PNIPAM), at the time a “young polymer” first …

How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

Rapidly developing technologies have recently fueled an exciting era of discovery in the
field of chromosome structure and nuclear organization. In addition to chromosome …

We describe Hi-C, a method that probes the three-dimensional architecture of whole
genomes by coupling proximity-based ligation with massively parallel sequencing. We …

Microscopy and genomic approaches provide detailed descriptions of the three-dimensional
folding of chromosomes and nuclear organization. The fundamental question is how activity …

In vivo, the human genome folds into a characteristic ensemble of 3D structures. The
mechanism driving the folding process remains unknown. We report a theoretical model for …

This review examines intermittent target search strategies, which combine phases of slow
motion, allowing the searcher to detect the target, and phases of fast motion during which …

The fractal globule is a compact polymer state that emerges during polymer condensation as
a result of topological constraints which prevent one region of the chain from passing across …

Chromosomes in the eukaryotic nucleus are highly compacted. However, for many
functional processes, including transcription initiation, the pairwise motion of distal …

Chromosome folding is modulated as cells progress through the cell cycle. During mitosis,
condensins fold chromosomes into helical loop arrays. In interphase, the cohesin complex …