The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …

Reverse transcription and integration are the defining features of the Retroviridae; the
common name “retrovirus” derives from the fact that these viruses use a virally encoded …

Elucidation of mutagenic processes shaping cancer genomes is a fundamental problem
whose solution promises insights into new treatment, diagnostic and prevention strategies …

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers
worldwide and the fourth most lethal cancer in China. However, although genomic studies …

The initiation, progression, and relapse of cancers often result from mutations occurring
within somatic cells. Consequently, processes that elevate mutation rates accelerate …

Host range is a viral property reflecting natural hosts that are infected either as part of a
principal transmission cycle or, less commonly, as “spillover” infections into alternative hosts …

A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in
the absence of medical interventions. Various innate and adaptive immune responses, as …

Successful intracellular pathogens must evade or neutralize the innate immune defenses of
their host cells and render the cellular environment permissive for replication. For example …

Post-transcriptional modifications have been recently expanded with the addition of RNA
editing, which is predominantly mediated by adenosine and cytidine deaminases acting on …

The human APOBEC3 proteins are DNA cytidine deaminases that impede the replication of
many different transposons and viruses. The genes that encode APOBEC3A, APOBEC3B …