Paclitaxel is an effective first-line chemotherapeutic with the major dose-limiting side effect of
painful neuropathy. Mitochondrial dysfunction and oxidative stress have been implicated in …

Background Hypoxic-ischaemic encephalopathy (HIE) is a prevailing severe brain damage
disease in newborns, and caused by perinatal asphyxia cerebral ischaemia and …

Stress seems to contribute to Parkinson's disease (PD) neuropathology, probably by
dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors in this …

Purpose.: Ourstudy aimed to establish a model of energetic and metabolic dysfunction to
cultured retinal cells by chemically inhibiting the mitochondrial electron transport chain with …

Statins induce acute vasorelaxation which may contribute to the overall benefits of statins in
the treatment of cardiovascular disease. The mechanism underlying this relaxation is …

PKC is implicated in the regulation of mitochondrial metabolism. We examined the
association of PKCβ with mitochondria and followed postischemic changes in its amount in …

In order to gain insight into the regulation of vascular tone by mitochondria, the effects of
mitochondrial complex III inhibitors on contractile responses in porcine isolated coronary …

La Enfermedad de Parkinson (EP), es el trastorno de movimiento más frecuente, siendo la
segunda causa de enfermedad neurodegenerativa en todo el mundo. Se caracteriza por la …

Sensory nerves detect conditions in the external and internal environment and permit
behavioral and physiological responses to maintain homeostasis and ensure survival. As …

Clinical trials have established the efficacy and safety of the 3-hydroxy-3-methylglutaryl-
coenzyme A (HMG-CoA) reductase inhibitors (statins) in lowering cardiovascular morbidity …