Noble metals in medicine: Latest advances

S Medici, M Peana, VM Nurchi, JI Lachowicz… - Coordination Chemistry …, 2015 - Elsevier
History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

Kinetics, mechanism and equilibrium studies on the substitution reactions of Pd (II) in reference to Pt (II) complexes with bio-molecules

ŽD Bugarčić, J Bogojeski, R van Eldik - Coordination Chemistry Reviews, 2015 - Elsevier
An overview of the research in the field of kinetics and mechanisms of substitution reactions
of Pd (II) complexes with sulfur and nitrogen donor bio-molecules is presented here. Pd (II) …

Michael addition-driven synthesis of cytotoxic palladium (ii) complexes from chromone thiosemicarbazones: investigation of anticancer activity through in vitro and in …

J Haribabu, N Balakrishnan, S Swaminathan… - New Journal of …, 2023 - pubs.rsc.org
Three Pd (II) complexes (1–3) containing tridentate chromone-based thiosemicarbazones
(SVSHL1–3) have been investigated as potential anticancer agents. The complexes of the …

Synthesis, spectroscopic, thermal and molecular modeling studies of Zn2+, Cd2+ and UO22+ complexes of Schiff bases containing triazole moiety. Antimicrobial …

M Gaber, HA El-Ghamry, SK Fathalla… - Materials Science and …, 2018 - Elsevier
A novel series of Zn 2+, Cd 2+ and UO 2 2+ complexes of ligands namely 1-[(5-mercapto-1H-
1, 2, 4-triazole-3-ylimino) methyl] naphthalene-2-ol (HL 1) and [(1H-1, 2, 4-triazole-3-ylimino) …

Synthesis, structures and mechanistic pathways of anticancer activity of palladium (II) complexes with indole-3-carbaldehyde thiosemicarbazones

J Haribabu, MM Tamizh, C Balachandran… - New Journal of …, 2018 - pubs.rsc.org
New PdII complexes of the types [PdCl (L)(PPh3)](1–5) and [Pd (L) 2](6 and 7)(HL= indole-3-
carbaldehyde thiosemicarbazones, HL1–HL5) have been synthesized in order to ascertain …

Chemical and biological evaluation of thiosemicarbazone-bearing heterocyclic metal complexes

AI Matesanz, JM Herrero… - Current topics in medicinal …, 2021 - ingentaconnect.com
Thiosemicarbazones (TSCNs) constitute a broad family of compounds (R1R2C= N-NH-C (S)-
NR3R4), particularly attractive because many of them display some biological activity …

Palladium (II) and platinum (II) bis (thiosemicarbazone) complexes of the 2, 6-diacetylpyridine series with high cytotoxic activity in cisplatin resistant A2780cisR tumor …

AI Matesanz, I Leitao, P Souza - Journal of Inorganic Biochemistry, 2013 - Elsevier
Preparation and characterization of four novel 2, 6-diacetylpyridine bis (4N-
tolylthiosemicarbazonato) palladium (II) and platinum (II) complexes,[PdL1–2] and [PtL1–2] …

Unprecedented formation of palladium (II)-pyrazole based thiourea from chromone thiosemicarbazone and [PdCl2 (PPh3) 2]: Interaction with biomolecules and …

J Haribabu, C Balachandran, MM Tamizh… - Journal of Inorganic …, 2020 - Elsevier
Two novel pyrazole based thiourea palladium (II) complexes,[PdCl (PPh 3)(C 9 H 8 NO 2 S-
pz)](1) and [PdCl (PPh 3)(C 14 H 10 NO 2 S-pz)](2)[pz= pyrazole (C 3 H 2 N 2)] have been …

Selective Buchwald–Hartwig arylation of C-amino-1, 2, 4-triazoles and other coordinating aminoheterocycles enabled by bulky NHC ligands and TPEDO activator

AV Astakhov, AY Chernenko, VV Kutyrev… - Inorganic Chemistry …, 2023 - pubs.rsc.org
C-Amino-1, 2, 4-triazoles are challenging polynitrogen substrates for metal-catalyzed
arylation due to their multidentate character, enhanced coordinating ability and decreased …

Two novel Pd thiosemicarbazone complexes as efficient and selective antitumoral drugs

T Hidalgo, D Fabra, R Allende, AI Matesanz… - Inorganic Chemistry …, 2023 - pubs.rsc.org
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in
2020. Palladium complexes can be used as anticancer and pharmacological agents as a …