Salivary glands sustain collateral damage following radiotherapy (RT) to treat cancers of the
head and neck, leading to complications, including mucositis, xerostomia and …

Radiation therapy for head and neck cancer causes significant secondary side-effects in
normal salivary glands, resulting in diminished quality of life for these individuals. Salivary …

The salivary glands often become damaged in individuals receiving radiotherapy for head
and neck cancer, resulting in chronic dry mouth. This leads to detrimental effects on their …

The ductal system of the salivary gland has long been postulated to be resistant to radiation-
induced damage, a common side effect incurred by head and neck cancer patients receiving …

Protein kinase C (PKC) δ is an essential regulator of mitochondrial dependent apoptosis in
epithelial cells. We have used the PKCδ-/-mouse to ask if loss of PKCδ protects salivary …

Background Radiotherapy for head and neck cancer results in severe and chronic salivary
gland dysfunction in most individuals. This results in significant side effects including …

Salivary gland acinar cells are severely depleted after radiotherapy for head and neck
cancer, leading to loss of saliva and extensive oro-digestive complications. With no …

Although often overlooked in our daily lives, saliva performs a host of necessary
physiological functions, including lubricating and protecting the oral cavity, facilitating taste …

This study aimed to elucidate the effect of 5-fluorouracil (5-FU) on the histological aspects of
the major salivary glands, salivary flow and saliva composition using an established oral …

PURPOSE: Radiotherapy for head-and-neck cancer consists of fractionated radiation
treatments that cause significant damage to salivary glands leading to chronic salivary gland …