The emerging era of lactate: A rising star in cellular signaling and its regulatory mechanisms
D Wu, K Zhang, FA Khan, Q Wu… - Journal of Cellular …, 2023 - Wiley Online Library
Cellular metabolites are ancient molecules with pleiotropic implications in health and
disease. Beyond their cognate roles, they have signaling functions as the ligands for specific …
disease. Beyond their cognate roles, they have signaling functions as the ligands for specific …
Visualizing physiological parameters in cells and tissues using genetically encoded indicators for metabolites
A San Martín, R Arce-Molina, C Aburto… - Free Radical Biology …, 2022 - Elsevier
The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …
A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice
Summary The ATP-sensitive K+(K ATP) channel is a key regulator of hormone secretion
from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in …
from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in …
Metabolic regulation of glucagon secretion
SL Armour, JE Stanley, J Cantley… - Journal of …, 2023 - joe.bioscientifica.com
Since the discovery of glucagon 100 years ago, the hormone, and the pancreatic islet alpha
cells that produce it, have remained enigmatic relative to insulin producing beta cells …
cells that produce it, have remained enigmatic relative to insulin producing beta cells …
Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-
stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an …
stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an …
LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic β cells
Using 13 C 6 glucose labeling coupled to gas chromatography-mass spectrometry and 2D 1
H-13 C heteronuclear single quantum coherence NMR spectroscopy, we have obtained a …
H-13 C heteronuclear single quantum coherence NMR spectroscopy, we have obtained a …
TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet
Summary Mitochondrial Ca 2+([Ca 2+] m) homeostasis is critical for β-cell function and
becomes disrupted during the pathogenesis of diabetes.[Ca 2+] m uptake is dependent on …
becomes disrupted during the pathogenesis of diabetes.[Ca 2+] m uptake is dependent on …
α-cell electrophysiology and the regulation of glucagon secretion
R Gao, S Acreman, J Ma, F Abdulkader… - Journal of …, 2023 - joe.bioscientifica.com
Glucagon is the principal glucose-elevating hormone that forms the first-line defence against
hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic …
hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic …
Expression of the GCG gene and secretion of active glucagon‐like peptide‐1 varies along the length of intestinal tract in horses
DM Fitzgerald, CM Cash, KJ Dudley… - Equine Veterinary …, 2024 - Wiley Online Library
Background Active glucagon‐like peptide‐1 (aGLP‐1) has been implicated in the
pathogenesis of equine insulin dysregulation (ID), but its role is unclear. Cleavage of …
pathogenesis of equine insulin dysregulation (ID), but its role is unclear. Cleavage of …
SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans
Abstract N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses
food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe …
food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe …