Cellular metabolites are ancient molecules with pleiotropic implications in health and
disease. Beyond their cognate roles, they have signaling functions as the ligands for specific …

The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …

Summary The ATP-sensitive K+(K ATP) channel is a key regulator of hormone secretion
from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in …

Since the discovery of glucagon 100 years ago, the hormone, and the pancreatic islet alpha
cells that produce it, have remained enigmatic relative to insulin producing beta cells …

Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-
stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an …

Using 13 C 6 glucose labeling coupled to gas chromatography-mass spectrometry and 2D 1
H-13 C heteronuclear single quantum coherence NMR spectroscopy, we have obtained a …

Summary Mitochondrial Ca 2+([Ca 2+] m) homeostasis is critical for β-cell function and
becomes disrupted during the pathogenesis of diabetes.[Ca 2+] m uptake is dependent on …

Glucagon is the principal glucose-elevating hormone that forms the first-line defence against
hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic …

Background Active glucagon‐like peptide‐1 (aGLP‐1) has been implicated in the
pathogenesis of equine insulin dysregulation (ID), but its role is unclear. Cleavage of …

Abstract N-lactoyl-phenylalanine (Lac-Phe) is a lactate-derived metabolite that suppresses
food intake and body weight. Little is known about the mechanisms that mediate Lac-Phe …