The regulation of gene expression in living organisms rests mainly upon the recognition of
nucleic acid base sequences by proteins [1, 2]. However, nucleic acids can also play a role …

The hammerhead ribozyme is one of the smallest ribozymes known and catalyses the site‐
specific hydrolysis of a phosphodiester bond. This small ribozyme is of interest for two …

Ribonuclease P (RNase P) from Escherichia coli or its catalytic RNA subunit can efficiently
cleave small RNA substrates that lack the conserved features of natural substrates of RNase …

Overexpression of TAR-containing sequences (TAR decoys) was used to render cells
resistant to HIV replication. A chimeric tRNAmr-TAR transcription unit contained in a double …

We describe a novel DNA and RNA found in the mitochondria of the Varkud-lc natural
isolate of Neurospora. The majority of the RNA, termed VSRNA, is an 881 nucleotide single …

The influence of chemical modifications on the catalytic activity and stability of a
hammerhead ribozyme directed against the long terminal repeat RNA of the human …

The invention pertains to a novel method and construct for regulating gene expression
through inhibition of gene expression by nuclear antisense RNA. The construct pro vides an …

Ribozymes have enormous potential as antiviral agents. We have previously reported that a
hairpin ribozyme expressed under the control of the beta-actin promoter that cleaves human …

The incorporation of histone H1 into chromatin during embryogenesis directs the specific
repression of the Xenopus oocyte 5S rRNA genes. An increase in histone H1 content …

Nucleic acids are increasingly being considered for therapeutic uses, either to interfere with
the function of specific nucleic acids or to bind specific proteins. Three types of nucleic acid …