This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …

Fluid and HCO3− secretion is a vital function of all epithelia and is required for the survival of
the tissue. Aberrant fluid and HCO3− secretion is associated with many epithelial diseases …

The heterogenous subcellular distribution of a wide array of channels, pumps and
exchangers allows extracellular stimuli to induce increases in cytoplasmic Ca2+ …

The endoplasmic reticulum (ER) in animal cells is an extensive, morphologically continuous
network of membrane tubules and flattened cisternae. The ER is a multifunctional organelle; …

▪ Abstract The secretion of fluid and electrolytes by salivary gland acinar cells requires the
coordinated regulation of multiple water and ion transporter and channel proteins. Notably …

Although the number of pathologies known to arise from the inappropriate folding of proteins
continues to grow, mechanisms underlying the recognition and ultimate disposition of …

Calcium ions are released from intracellular stores in response to agonist-stimulated
production of inositol 1, 4, 5-trisphosphate (InsP3), a second messenger generated at the …

Inositol 1, 4, 5‐trisphosphate (IP 3) plays a key role in Ca 2+ signalling, which exhibits a
variety of spatio‐temporal patterns that control important cell functions. Multiple subtypes of …

Ca2+ is one of the most important messengers. It transmits signals inside living cells and
takes part in intercellular coordination. The dynamics of the Ca2+ concentration shows a …