The adrenal gland controls a plethora of crucial physiological functions, and dysfunction is
associated with severe morbidity. Because of the vital importance of appropriate adrenal …

The cortex of the adrenal gland is organized into concentric zones that produce distinct
steroid hormones essential for body homeostasis in mammals. Mechanisms leading to the …

Adrenal cortex steroids are essential for body homeostasis, and adrenal insufficiency is a life-
threatening condition. Adrenal endocrine activity is maintained through recruitment of …

Transcription factor GATA4 is expressed in somatic cells of the mammalian testis. Gene
targeting studies in mice have shown that GATA4 is essential for proper differentiation and …

Conditional deletion of Gata4 in Sertoli cells (SCs) of adult mice has been shown to increase
permeability of the blood-testis barrier (BTB) and disrupt spermatogenesis. To gain insight …

Transcription factor GATA6 is expressed in the fetal and adult adrenal cortex and has been
implicated in steroidogenesis. To characterize the role of transcription factor GATA6 in …

Background: Stress exposure exerts direct effects on the morphology and functionality of the
adrenal cortex. In addition, ageing effects growth, differentiation, apoptosis and cellularity of …

DNA methylation is a mechanism for long-term transcriptional regulation and is required for
normal cellular differentiation. Failure to properly establish or maintain DNA methylation …

Gonadectomy (GDX) induces sex steroid-producing adrenocortical tumors in certain mouse
strains and in the domestic ferret. Transcriptome analysis and DNA methylation mapping …

GATA transcription factors are structurally-related zinc finger proteins that recognize the
consensus DNA sequence WGATAA (the GATA motif), an essential cis-acting element in the …