Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

We review approaches aimed at deciphering the physical mechanisms responsible for viral
structure and assembly. We discuss the basic principles of condensed matter physics …

Macromolecular complexes are intrinsically flexible and often challenging to purify for
structure determination by single-particle cryo-electron microscopy (cryo-EM). Such …

HIV-1 Gag metamorphoses inside each virion, from an immature lattice that forms during
viral production to a mature capsid that drives infection. Here we show that the immature …

HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered
membrane microdomains. The size and stability of membrane microdomains is regulated by …

The maturation of HIV-1 capsid protein (CA) into a cone-shaped lattice capsid is critical for
viral infectivity. CA can self-assemble into a range of capsid morphologies made of~ 175 to …

Retroviruses assemble and bud from infected cells in an immature form and require
proteolytic maturation for infectivity. The CA (capsid) domains of the Gag polyproteins …

Human immunodeficiency virus-1 capsid (HIV-1 CA) is involved in different stages of the
viral replication cycle. During virion assembly, CA drives the formation of the hexameric …

During retrovirus maturation, cleavage of the precursor structural Gag polyprotein by the
viral protease induces architectural rearrangement of the virus particle from an immature into …

While small single-stranded viral shells encapsidate their genome spontaneously, many
large viruses, such as the herpes simplex virus or infectious bursal disease virus (IBDV) …