Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

Cells sense and respond to the physical properties of their environment through receptor-
mediated signaling, a process known as mechanotransduction, which can modulate critical …

Biofabrication techniques enable the performance of bioinspired three‐dimensional (3D)
matrices resembling primary tumors. To validate their reliability, embedded cells may …

The plasma membrane is widely regarded as the hub of the numerous signal transduction
activities. Yet, the fundamental biophysical mechanisms that spatiotemporally …

The phase field model can accurately simulate the evolution of microstructures with complex
morphologies, and it has been widely used for cell modeling in the last two decades …

The motility of adherent eukaryotic cells is driven by the dynamics of the actin cytoskeleton.
Despite the common force-generating actin machinery, different cell types often show …

Neutrophils undergo fast migration dynamics onto endothelium or extracellular matrix using
anterior protrusion together with posterior contraction and retraction. While these migrating …

In this work, we studied the generation and rising of polyploid cancer cells as a product of
mechanical stress. To this purpose, MCF7 breast cancer cells were cultured on 2D (ie …

Symmetry breaking, polarity establishment, and spontaneous cell protrusion formation are
fundamental but poorly explained cell behaviors. Here, we demonstrate that a biochemical …

Traction-force microscopy (TFM) has emerged as a widely used standard methodology to
measure cell-generated traction forces and determine their role in regulating cell behavior …