Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …

Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …

Equipping cancer-fighting immune cells with chimeric antigen receptor (CAR) has gained
immense attention for cancer treatment. CAR-engineered T cells (CAR T cells) are the first …

Fibroblasts, derived from the embryonic mesenchyme, are a diverse array of cells with roles
in development, homeostasis, repair, and disease across tissues. In doing so, fibroblasts …

The cancer-associated fibroblast (CAF) barrier in pancreatic ductal adenocarcinoma (PDAC)
greatly restricts clinical outcomes. Major obstacles to PDAC treatment include restricted …

Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor
occurrence and development for its ability to study gene expression at the individual cell …

Anti-PD-1/PD-L1 therapy has shown significant benefits in the treatment of a variety of
malignancies. However, not all cancer patients can benefit from this strategy due to drug …

Mounting evidence has found that tumor microenvironment (TME) plays an important role in
the tumor progression of lung adenocarcinoma (LUAD). However, the roles of tumor …

Background Tumor heterogeneity plays essential roles in developing cancer therapies,
including therapies for breast cancer (BC). In addition, it is also very important to understand …

Abstract Background Cancer-associated fibroblasts (CAFs), an important component of the
tumor microenvironment (TME), play crucial roles in tumor stemness. It has been shown in …