Systems biology approaches to identify potential targets and inhibitors of the intestinal microbiota to treat depression

F Teng, Z Lu, F Gao, J Liang, J Li, X Tian, X Wang… - Scientific reports, 2023 - nature.com
Depression is a common mental disease, with some patients exhibiting ideas and behaviors
such as self-harm and suicide. The drugs currently used to treat depression have not …

Molecular and functional characterization of different BrainSphere models for use in neurotoxicity testing on microelectrode arrays

J Hartmann, N Henschel, K Bartmann, A Dönmez… - Cells, 2023 - mdpi.com
The currently accepted methods for neurotoxicity (NT) testing rely on animal studies.
However, high costs and low testing throughput hinder their application for large numbers of …

An adult-stage transcriptional program for survival of serotonergic connectivity

MM Kitt, N Tabuchi, WC Spencer, HL Robinson… - Cell reports, 2022 - cell.com
Neurons must function for decades of life, but how these non-dividing cells are preserved is
poorly understood. Using mouse serotonin (5-HT) neurons as a model, we report an adult …

[HTML][HTML] Environmental fluoxetine promotes skin cell proliferation and wound healing

Q Rodriguez-Barucg, AA Garcia, B Garcia-Merino… - Environmental …, 2024 - Elsevier
This study investigates the effects of environmentally-relevant concentrations of fluoxetine
(FLX, commercial name: Prozac) on wound healing. Pollution of water systems with …

Citalopram exposure of hESCs during neuronal differentiation identifies dysregulated genes involved in neurodevelopment and depression

M Spildrejorde, M Leithaug, A Samara… - Frontiers in Cell and …, 2024 - frontiersin.org
Selective serotonin reuptake inhibitors (SSRIs), including citalopram, are widely used
antidepressants during pregnancy. However, the effects of prenatal exposure to citalopram …

[HTML][HTML] Inhibition of Ionic Currents by Fluoxetine in Vestibular Calyces in Different Epithelial Loci

NMM Mohamed, FL Meredith, KJ Rennie - International Journal of …, 2024 - mdpi.com
Previous studies have suggested a role for selective serotonin reuptake inhibitors (SSRIs)
such as fluoxetine (Prozac®) in the treatment of dizziness and inner ear vestibular …

[HTML][HTML] Assessing the Neurodevelopmental Impact of Fluoxetine, Citalopram, and Paroxetine on Neural Stem Cell-Derived Neurons

K Hosseini, A Cediel-Ulloa, MH Al-Sabri, A Forsby… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: Many pregnant women globally suffer from depression and are
routinely prescribed selective serotonin reuptake inhibitors (SSRIs). These drugs function by …

Влияние неонатальной гипоксии и антидепрессанта флуоксетина на когнитивную и стресс-гормональную функции у взрослых крыс

ВА Михайленко, ИП Буткевич… - Журнал эволюционной …, 2023 - rusjphysiol.org
Аннотация У взрослых самцов и самок крыс, подвергнутых на 2-й день жизни
умеренной острой гипоксии и затем хроническому введению ингибитора обратного …

The modulatory effect of Al-Assi river trout fish meal on OCD manifestations and molecular mechanisms in BALB/c Mice

F Salloum, M Farran, H Shaib, A Jurjus… - Functional Foods in …, 2024 - ffhdj.com
Background: Obsessive-Compulsive Disorder (OCD) is a type of anxiety disorder that is
marked by intrusive and distressing thoughts, as well as repetitive behaviors. Trout fish …

Effects of Neonatal Hypoxia and Antidepressant Fluoxetine on Cognitive and Stress-Hormonal Functions in Adult Rats

VA Mikhailenko, IP Butkevich, EA Vershinina - Journal of Evolutionary …, 2023 - Springer
Spatial learning and the functionality of spatial memory, as well as the stressful reactivity of
the hypothalamus–pituitary–adrenocortical axis (the HPA axis) were investigated in adult …