Improved understanding of interactions between nanoparticles and biological systems is
needed to develop safety standards and to design new generations of nanomaterials. This …

Many applications of nanomedicines depend on the therapeutic gaining access to the
interior of cells. As most proteins and nanoparticles are taken up by endocytosis …

Enabling macrophages to phagocytose tumor cells holds great potential for cancer therapy
but suffers from tremendous challenges because the tumor cells upregulate …

Direct delivery of proteins into cells avoids many drawbacks of gene delivery, and thus has
emerging applications in biotherapy. However, it remains a challenging task owing to limited …

Neutrophils rely predominantly on glycolytic metabolism for their biological functions,
including reactive oxygen species (ROS) production. Although pyruvate kinase M2 (PKM2) …

The penetration behavior of nanoparticles in mucous depends on physicochemical
properties of the nanoparticles and the mucus microenvironment, due to particle–mucin …

C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in
response to inflammatory reactions. We recently identified a novel mechanism that leads to …

The efficacy of fast synaptic inhibition is critically dependent on the accumulation of GABAA
receptors at inhibitory synapses, a process that remains poorly understood. Here, we …

Background The uptake of nanoparticles (NPs) by cells remains to be better characterized in
order to understand the mechanisms of potential NP toxicity as well as for a reliable risk …

Macrophages provide a bridge linking innate and adaptive immunity. An increased
frequency of macrophages and other myeloid cells paired with excessive cytokine …