Infections represent a common health problem in people of all ages. Usually, the response
given to them is appropriate and so little treatment is needed. Sometimes, however, the …

Rapid and accurate profiling of infection-causing pathogens remains a significant challenge
in modern health care. Despite advances in molecular diagnostic techniques, blood culture …

Combination antibiotic therapy for invasive infections with Gram-negative bacteria is
employed in many health care facilities, especially for certain subgroups of patients …

Sepsis has been around since the dawn of time, having been described for more than 2000
years, although clinical definitions are recent. The consensus sepsis definitions have …

Objectives Sepsis guidelines recommend obtaining blood cultures before starting anti-
infective therapy in patients with sepsis. However, little is known of how antibiotic treatment …

Introduction The impact of in vitro resistance on initially appropriate antibiotic therapy (IAAT)
remains unclear. We elucidated the relationship between non-IAAT and mortality, and …

Objective Our goal was to determine the impact of the initiation of inappropriate antimicrobial
therapy on survival to hospital discharge of patients with septic shock. Methods The …

EXECUTIVE SUMMARY Since the initial 1996 American Thoracic Society (ATS) guideline
on nosocomial pneumonia, a number of new developments have appeared, mandating a …

Purposes We set out to assess the safety and the impact on in-hospital and 90-day mortality
of antibiotic de-escalation in patients admitted to the ICU with severe sepsis or septic shock …

Quantifying the benefit of early antibiotic treatment is crucial for decision making and can be
assessed only in observational studies. We performed a systematic review of prospective …