Besides the typical whooping cough syndrome, infection with Bordetella pertussis or
immunization with whole-cell vaccines can result in a wide variety of physiological …

Pertussis toxin (PT) is considered the main virulence factor causing whooping cough or
pertussis. The protein is widely studied and its composition was revealed and sequenced …

Bordetella pertussis whole-cell vaccines (wP) caused a spectacular drop of global pertussis
incidence, but since the replacement of wP with acellular pertussis vaccines (aP), pertussis …

Abstract Background In Germany, antenatal influenza vaccination is recommended since
2010, but uptake remains low. Several countries recently introduced antenatal pertussis …

Background Recombinant pertussis vaccines inducing long-lasting immune responses
could help to control the rise in pertussis. We here report on persisting antibody responses 2 …

Introduction Whole cell and acellular pertussis vaccines have been very effective in
decreasing the deaths of neonates and infants from Bordetella pertussis. Despite high …

Effective diphtheria, tetanus toxoids, whole-cell pertussis (wP) vaccines were used for
massive immunization in the 1950s. The broad use of these vaccines significantly reduced …

Objectives Protection induced by acellular vaccines can be short, requiring novel
immunization strategies. Objectives of this study were to evaluate safety and capacity of a …

Neither immunization nor recovery from natural infection provides life-long protection
against Bordetella pertussis. Replacement of a whole-cell pertussis (wP) vaccine with an …

Whooping cough is caused by the bacterium Bordetella pertussis. There are currently two
types of vaccines that can prevent the disease; whole cell vaccines (WCV) and acellular …