Targeting two-pore channels: current progress and future challenges

X Jin, Y Zhang, A Alharbi, A Hanbashi… - Trends in …, 2020 - cell.com
Two-pore channels (TPCs) are cation-permeable channels located on endolysosomal
membranes and important mediators of intracellular Ca 2+ signalling. TPCs are involved in …

Nanotechnology applications of flavonoids for viral diseases

K Jannat, AK Paul, TA Bondhon, A Hasan, M Nawaz… - Pharmaceutics, 2021 - mdpi.com
Recent years have witnessed the emergence of several viral diseases, including various
zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory …

Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro

N Clementi, C Scagnolari, A D'Amore… - Pharmacological …, 2020 - pmc.ncbi.nlm.nih.gov
Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro - PMC Skip to main content
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Perspective: The potential effects of naringenin in COVID-19

RW Alberca, FME Teixeira, DR Beserra… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome
Coronavirus-2 (SARS-CoV-2), was declared a pandemic by the World Health Organization …

Role of endolysosomes in severe acute respiratory syndrome coronavirus-2 infection and coronavirus disease 2019 pathogenesis: implications for potential …

N Khan, X Chen, JD Geiger - Frontiers in pharmacology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an enveloped, single-
stranded RNA virus. Humans infected with SARS-CoV-2 develop a disease known as …

Naringenin as a possible candidate against SARS-CoV-2 infection and in the pathogenesis of COVID-19

PK Agrawal, C Agrawal… - Natural Product …, 2021 - journals.sagepub.com
Naringenin, widely distributed in fruits and vegetables, is endowed with antiviral and other
health beneficial activities, such as immune-stimulating and anti-inflammatory actions that …

Could the inhibition of endo-lysosomal two-pore channels (TPCs) by the natural flavonoid naringenin represent an option to fight SARS-CoV-2 infection?

A Filippini, A D'Amore, F Palombi… - Frontiers in …, 2020 - frontiersin.org
In the present opinion article we highlight evidence from different laboratories to drive the
attention of the scientific community on the role played by endo-lysosomal Two-Pore …

[HTML][HTML] Possible therapeutic use of natural compounds against COVID-19

N Khan, X Chen, JD Geiger - Journal of cellular signaling, 2021 - ncbi.nlm.nih.gov
The outbreak of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to
coronavirus disease-19 (COVID-19); a pandemic disease that has resulted in devastating …

Calcium mobilization in endothelial cell functions

A Filippini, A D'Amore, A D'Alessio - International journal of molecular …, 2019 - mdpi.com
Endothelial cells (ECs) constitute the innermost layer that lines all blood vessels from the
larger arteries and veins to the smallest capillaries, including the lymphatic vessels. Despite …

Scutellaria barbata D. Don Inhibits the Main Proteases (Mpro and TMPRSS2) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

ST Huang, Y Chen, WC Chang, HF Chen, HC Lai… - Viruses, 2021 - mdpi.com
In late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
emerged to severely impact the global population, creating an unprecedented need for …