[HTML][HTML] Customizing cellular signal processing by synthetic multi-level regulatory circuits

Y Gao, L Wang, B Wang - Nature Communications, 2023 - nature.com
As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …

Synthetic genetic circuits for programmable biological functionalities

PF Xia, H Ling, JL Foo, MW Chang - Biotechnology advances, 2019 - Elsevier
Living organisms evolve complex genetic networks to interact with the environment. Due to
the rapid development of synthetic biology, various modularized genetic parts and units …

[HTML][HTML] Advances in synthetic-biology-based whole-cell biosensors: Principles, genetic modules, and applications in food safety

S Chen, X Chen, H Su, M Guo, H Liu - International Journal of Molecular …, 2023 - mdpi.com
A whole-cell biosensor based on synthetic biology provides a promising new method for the
on-site detection of food contaminants. The basic components of whole-cell biosensors …

Biosensor-guided discovery and engineering of metabolic enzymes

HG Hwang, DY Ye, GY Jung - Biotechnology Advances, 2023 - Elsevier
A variety of chemicals have been produced through metabolic engineering approaches, and
enhancing biosynthesis performance can be achieved by using enzymes with high catalytic …

[HTML][HTML] Signal amplification and optimization of riboswitch-based hybrid inputs by modular and titratable toehold switches

Y Hwang, SG Kim, S Jang, J Kim, GY Jung - Journal of biological …, 2021 - Springer
Background Synthetic biological circuits are widely utilized to control microbial cell functions.
Natural and synthetic riboswitches are attractive sensor modules for use in synthetic biology …

Active Analyte Import Improves the Dynamic Range and Sensitivity of a Vitamin B12 Biosensor

MP McNerney, F Piorino, CL Michel… - ACS synthetic …, 2020 - ACS Publications
Cell-free systems provide a versatile platform for the development of low-cost, easy-to-use
sensors for diverse analytes. However, sensor affinity dictates response sensitivity, and …

Recent advances in microbial cell growth regulation strategies for metabolic engineering

MH Noh, S Cha, M Kim, GY Jung - Biotechnology and Bioprocess …, 2020 - Springer
Programming a new function into cells and balancing new functions with native cellular
metabolism or program related to cell growth have long been a challenge in metabolic …

Third generation whole-cell sensing systems: synthetic biology inside, nanomaterial outside

M Guo, K Huang, W Xu - Trends in Biotechnology, 2021 - cell.com
Whole-cell sensing systems (WCSSs) are highly anticipated in the field of on-site detection.
However, due to their low specificity, poor stability, and potential environmental problems …

[HTML][HTML] A hybrid RNA-protein biosensor for high-throughput screening of adenosylcobalamin biosynthesis

X Yang, H Wang, D Ding, H Fang, H Dong… - Synthetic and Systems …, 2024 - Elsevier
Genetically encoded circuits have been successfully utilized to assess and characterize
target variants with desirable traits from large mutant libraries. Adenosylcobalamin is an …

微生物传感器在食品分析中的应用.

苏东海, 陈诗静, 郭明璋, 刘慧琳… - Journal of Food …, 2023 - search.ebscohost.com
微生物传感器是以活体微生物细胞为感应元件, 感应需要测定的靶标物质浓度并按照一定规律
转换为可识别信号的检测装置. 早期的微生物传感器以微生物测定和微生物电极的形式出现 …