Meiosis is a specialized cell division program that is essential for sexual reproduction. The
two meiotic divisions reduce chromosome number by half, typically generating haploid …

The shugoshin/Mei-S332 family are proteins that associate with the chromosomal region
surrounding the centromere (the pericentromere) and that play multiple and distinct roles in …

During meiosis, crossover recombination is essential to link homologous chromosomes and
drive faithful chromosome segregation. Crossover recombination is non-random across the …

The cell cycle is ordered by a controlled network of kinases and phosphatases. To generate
gametes via meiosis, two distinct and sequential chromosome segregation events occur …

Studies on budding yeast have exposed the highly conserved mechanisms by which
duplicated chromosomes are evenly distributed to daughter cells at the metaphase …

While the importance of protein kinases for the spatial and temporal control of mitotic events
has long been recognized, mitotic phosphatases have only recently come into the limelight …

Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle
assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion …

To protect against aneuploidy, chromosomes must attach to microtubules from opposite
poles ('biorientation') prior to their segregation during mitosis. Biorientation relies on the …

The cohesin complex holds sister chromatids together from the time of their duplication in S
phase until their separation during mitosis. Although cohesin is found along the length of …

Protein phosphatase 2A‐(PP2A‐) catalyzed dephosphorylation of target substrate proteins
is widespread and critical for cellular function. PP2A is predominantly found as a …