Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …

Bone is a dynamic tissue and is constantly being remodeled by bone cells. Metabolic
reprogramming plays a critical role in the activation of these bone cells and skeletal …

Osteoporosis has a profound influence on public health. First-line bisphosphonates often
cause osteonecrosis of the jaw meanwhile inhibiting osteoclasts. Therefore, it is important to …

Kaempferol, a flavonoid compound, is derived from the rhizome of Kaempferia galanga L.,
which is used in traditional medicine in Asia. Autophagy has pleiotropic functions that are …

Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce
osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms …

Background Here we study the effect of type 2 diabetes (T2DM) on bone cell precursors,
turnover and cytokines involved in the control of bone cell formation and activity. Methods …

It is well known that extensive osteoclast formation plays a key role in osteoporosis in post‑
menopausal women and the elderly. The suppression of extensive osteoclastogenesis and …

Previous studies have implicated autophagy in osteoclast differentiation. The aim of this
study was to investigate the potential role of p62, a characterized adaptor protein for …

MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that represent important
posttranscriptional regulators of protein-encoding genes. In particular, miRNAs play key …

Bones serve mechanical and defensive functions, as well as regulating the balance of
calcium ions and housing bone marrow.. The qualities of bones do not remain constant …