[HTML][HTML] Co–culture systems of osteoblasts and osteoclasts: Simulating in vitro bone remodeling in regenerative approaches
G Borciani, G Montalbano, N Baldini, G Cerqueni… - Acta biomaterialia, 2020 - Elsevier
Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …
Regulation of osteoclast differentiation and activity by lipid metabolism
H Kim, B Oh, KH Park-Min - Cells, 2021 - mdpi.com
Bone is a dynamic tissue and is constantly being remodeled by bone cells. Metabolic
reprogramming plays a critical role in the activation of these bone cells and skeletal …
reprogramming plays a critical role in the activation of these bone cells and skeletal …
Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption
JG Yang, B Sun, Z Wang, X Li, J Gao, J Qian, J Li… - Cell Death & …, 2023 - nature.com
Osteoporosis has a profound influence on public health. First-line bisphosphonates often
cause osteonecrosis of the jaw meanwhile inhibiting osteoclasts. Therefore, it is important to …
cause osteonecrosis of the jaw meanwhile inhibiting osteoclasts. Therefore, it is important to …
The effects of kaempferol-inhibited autophagy on osteoclast formation
CJ Kim, SH Shin, BJ Kim, CH Kim, JH Kim… - International journal of …, 2018 - mdpi.com
Kaempferol, a flavonoid compound, is derived from the rhizome of Kaempferia galanga L.,
which is used in traditional medicine in Asia. Autophagy has pleiotropic functions that are …
which is used in traditional medicine in Asia. Autophagy has pleiotropic functions that are …
Nox4 promotes RANKL-induced autophagy and osteoclastogenesis via activating ROS/PERK/eIF-2α/ATF4 pathway
J Sun, W Chen, S Li, S Yang, Y Zhang, X Hu… - Frontiers in …, 2021 - frontiersin.org
Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce
osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms …
osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms …
Type 2 diabetes affects bone cells precursors and bone turnover
F Sassi, I Buondonno, C Luppi, E Spertino… - BMC Endocrine …, 2018 - Springer
Background Here we study the effect of type 2 diabetes (T2DM) on bone cell precursors,
turnover and cytokines involved in the control of bone cell formation and activity. Methods …
turnover and cytokines involved in the control of bone cell formation and activity. Methods …
[HTML][HTML] Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways
XL Huang, LY Huang, YT Cheng… - International …, 2019 - spandidos-publications.com
It is well known that extensive osteoclast formation plays a key role in osteoporosis in post‑
menopausal women and the elderly. The suppression of extensive osteoclastogenesis and …
menopausal women and the elderly. The suppression of extensive osteoclastogenesis and …
The adaptor protein p62 is involved in RANKL-induced autophagy and osteoclastogenesis
Previous studies have implicated autophagy in osteoclast differentiation. The aim of this
study was to investigate the potential role of p62, a characterized adaptor protein for …
study was to investigate the potential role of p62, a characterized adaptor protein for …
MicroRNAs: key regulators to understand osteoclast differentiation?
C Lozano, I Duroux-Richard, H Firat… - Frontiers in …, 2019 - frontiersin.org
MicroRNAs (miRNAs) are small non-coding single-stranded RNAs that represent important
posttranscriptional regulators of protein-encoding genes. In particular, miRNAs play key …
posttranscriptional regulators of protein-encoding genes. In particular, miRNAs play key …
Role and regulation of transcription factors in osteoclastogenesis
T Jiang, T Xia, F Qiao, N Wang, Y Jiang… - International Journal of …, 2023 - mdpi.com
Bones serve mechanical and defensive functions, as well as regulating the balance of
calcium ions and housing bone marrow.. The qualities of bones do not remain constant …
calcium ions and housing bone marrow.. The qualities of bones do not remain constant …