In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

Molecular mechanisms of ovarian aging and female age-related fertility decline remain
unclear. We surveyed the single-cell transcriptomic landscape of ovaries from young and …

Ovarian granulosa cells (GCs) proliferate and differentiate along with follicular growth, and
this is indispensable for oocyte development and female fertility. Although the role of …

In women, the non-growing population of follicles that comprise the ovarian reserve is
determined at birth and serves as the reservoir for future fertility. This reserve of dormant …

The role of growth hormone (GH) in human fertility is widely debated with some studies
demonstrating improvements in oocyte yield, enhanced embryo quality, and in some cases …

Background PCOS is a reproductive hormonal abnormality and a metabolic disorder. It is
frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and …

The ovary is the first organ to age in humans with functional decline evident already in
women in their early 30s. Reproductive aging is characterized by a decrease in oocyte …

Granulosa cells are essential for follicle initiation and development, and their abnormal
function or apoptosis is a crucial factor leading to follicular atresia. A state of oxidative stress …

Although androgen excess is considered detrimental to women's health and fertility, global
and ovarian granulosa cell-specific androgen-receptor (AR) knockout mouse models have …