Today, clinical evaluation of tumor heterogeneity is an emergent issue to improve clinical
oncology. In particular, intra-tumor heterogeneity (ITH) is closely related to cancer …

Our defenses against infection rely on the ability of the immune system to distinguish
invading pathogens from self. This task is exceptionally challenging, if not seemingly …

Overcoming intrinsic resistance to immune checkpoint blockade for microsatellite stable
(MSS) colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) remains …

Transposable elements (TEs) help shape the structure and function of the human genome.
When inserted into some locations, TEs may disrupt gene regulation and cause diseases …

Altered RNA expression of repetitive sequences and retrotransposition are frequently seen
in colorectal cancer, implicating a functional importance of repeat activity in cancer …

Genomic instability and genetic mutations can lead to exhibition of several cancer hallmarks
in affected cells such as sustained proliferative signaling, evasion of growth suppression …

Cancer immunotherapy has dramatically changed the approach to cancer treatment. The
aim of targeting the immune system to recognize and destroy cancer cells has afforded …

Aberrant expression of viral-like repeat elements is a common feature of epithelial cancers,
and the substantial diversity of repeat species provides a distinct view of the cancer …

It has been posited that anti-tumoral innate activation is driven by derepression of
endogenous repeats. We compared RNA sequencing protocols to assess repeat …

Dysregulated endogenous retroelements (EREs) are increasingly implicated in the initiation,
progression, and immune surveillance of human cancer. However, incomplete knowledge of …