[HTML][HTML] Approaches for corneal endothelium regenerative medicine

P Catala, G Thuret, H Skottman, JS Mehta… - Progress in retinal and …, 2022 - Elsevier
The state of the art therapy for treating corneal endothelial disease is transplantation.
Advances in the reproducibility and accessibility of surgical techniques are increasing the …

Animal models in eye research: focus on corneal pathologies

A Loiseau, G Raîche-Marcoux, C Maranda… - International Journal of …, 2023 - mdpi.com
The eye is a complex sensory organ that enables visual perception of the world. The
dysfunction of any of these tissues can impair vision. Conduction studies on laboratory …

An effective method for culturing functional human corneal endothelial cells using a xenogeneic free culture medium

S Alonso-Alonso, N Vázquez, M Chacón… - Scientific reports, 2023 - nature.com
Endothelial dysfunction is a leading cause of corneal blindness in developed countries and
the only available treatment is the endothelial transplantation. However, the limited …

[HTML][HTML] Animal models of corneal endothelial dysfunction to facilitate development of novel therapies

S Park, BC Leonard, VK Raghunathan… - Annals of …, 2021 - ncbi.nlm.nih.gov
Progressive corneal endothelial disease eventually leads to corneal edema and vision loss
due to the limited regenerative capacity of the corneal endothelium in vivo and is a major …

Early and late-onset cell migration from peripheral corneal endothelium

A Miron, S Ní Dhubhghaill, V Kocaba, MJ Jager… - PLoS …, 2023 - journals.plos.org
In this study we describe peripheral corneal endothelial cell migration in vitro in the absence
and presence of a ROCK-inhibitor. For this study, 21 corneal endothelial graft rims, with …

Temperature Dependence of Membrane Permeability Parameters for Five Cell Types Using Nonideal Thermodynamic Assumptions to Mathematically Model …

F Yadegari, LA Gabler Pizarro… - The Journal of …, 2024 - ACS Publications
Cryopreservation is the process of preserving biological matter at subzero temperatures for
long-term storage. During cryopreservation, cells are susceptible to various injuries that can …

[HTML][HTML] Towards Clinical Application: Calcium Waves for In Vitro Qualitative Assessment of Propagated Primary Human Corneal Endothelial Cells

XY Ng, G Peh, F Morales-Wong, R Gabriel, PL Soong… - Cells, 2024 - mdpi.com
Corneal endothelium cells (CECs) regulate corneal hydration between the leaky barrier of
the corneal endothelium and the ionic pumps on the surface of CECs. As CECs do not …

Beneficial effects of polydeoxyribonucleotide (PDRN) in an in vitro model of fuchs endothelial corneal dystrophy

I Ceravolo, F Mannino, N Irrera, L Minutoli, V Arcoraci… - Pharmaceuticals, 2022 - mdpi.com
Fuchs endothelial corneal dystrophy (FECD) is a bilateral, hereditary syndrome
characterized by progressive irreversible injury in the corneal endothelium; it is the most …

Long-term observation after transplantation of cultured human corneal endothelial cells for corneal endothelial dysfunction

P Sun, L Shen, YB Li, LQ Du, XY Wu - Stem Cell Research & Therapy, 2022 - Springer
Background Corneal transplantation is the only way to treat serious corneal diseases
caused by corneal endothelial dysfunction. However, the shortage of donor corneal tissues …

Medizinische Ansätze zur Regeneration des Hornhautendothels

P Català, G Thuret, H Skottman, JS Mehta… - Kompass …, 2023 - karger.com
Zusammenfassung Die modernste Therapie zur Behandlung von
Hornhautendothelerkrankungen ist die Transplantation. Fortschritte in der …