Revisiting the neurovascular unit
S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
Regulation of blood–brain barrier integrity by microglia in health and disease: a therapeutic opportunity
PT Ronaldson, TP Davis - Journal of Cerebral Blood Flow & …, 2020 - journals.sagepub.com
The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …
Emerging roles for CNS fibroblasts in health, injury and disease
CE Dorrier, HE Jones, L Pintarić… - Nature Reviews …, 2022 - nature.com
Recent transcriptomic, histological and functional studies have begun to shine light on the
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …
Pericyte control of blood flow across microvascular zones in the central nervous system
DA Hartmann, V Coelho-Santos… - Annual review of …, 2022 - annualreviews.org
The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …
understanding of blood flow control remains incomplete. This review synthesizes current …
The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …
the aging world population. Advances in neurovascular biology have revealed an intricate …
Pericytes and neurovascular function in the healthy and diseased brain
Pericytes are multi-functional cells embedded within the walls of capillaries throughout the
body, including the brain. Pericytes were first identified in the 1870s, but little attention was …
body, including the brain. Pericytes were first identified in the 1870s, but little attention was …
Brain capillary pericytes exert a substantial but slow influence on blood flow
The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
Contractile pericytes determine the direction of blood flow at capillary junctions
AL Gonzales, NR Klug… - Proceedings of the …, 2020 - National Acad Sciences
The essential function of the circulatory system is to continuously and efficiently supply the
O2 and nutrients necessary to meet the metabolic demands of every cell in the body, a …
O2 and nutrients necessary to meet the metabolic demands of every cell in the body, a …
Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
Single-cell analysis of blood-brain barrier response to pericyte loss
MA Mäe, L He, S Nordling… - Circulation …, 2021 - Am Heart Assoc
Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood
vessels during development and tissue repair. Loss of pericytes has been described in …
vessels during development and tissue repair. Loss of pericytes has been described in …